Gene: [19p12/PAR4] proteinase activated (protease-activated) receptor 4;
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COM |
The PAR4 gene was mapped to 19p12 by FISH (Xu-1998). |
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FUN |
Studies with PAR-activating peptides suggest that PAR4 functions in human platelets, which implies that an analogous dual-receptor system operates in humans as well as in mice. The identification of a 2-receptor system for platelet activation by thrombin has important implications for the development of antithrombotic therapies (Xu-1998)." |
|
REF |
FUN,EXP "Kahn ML &: Nature, 394, 690-694, 1998 COD,SEQ,LOC "Xu W-F &: PNAS, 95, 6642-6646, 1998 |
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KEY |
hem, clot, recp |
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CLA |
coding, basic |
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LOC |
19 p12 |
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MIM |
MIM: 602779 |
