Gene: [19p133/PGK2] phosphoglycerate kinase 2 (of spermatozoa);

GEN

The gene length is 1725 bp (or more). There are no introns (McGarry-1987).

FUN

[1] Systematic name: ATP:3-phospho-D-glycerate phosphotransferase.
[2] Catalyzes reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate."

EVO

PGK2 gene is apparently a retroposon derivative of the aberrant PGK1 gene (GEM:0Xq133/PGK1). McGarry-1987 explained the unusual fact of retaining the function in the processed PGK2 gene and the tissue specificity of its expression by the compensatory reaction to inactivation of the X-linked gene PGK1 in spermatogenetic cells (before the meiosis)."

FAG

See GEM:0Xq133/PGK1.

PRO

[1] Gene-specific DNA probe PGK2 contains a 3.3 kb gDNA fragment, including (McGarry-1987) the coding sequence (1251 bp) + the 5'-flanking sequence (1.4 kb) + the 3'-flanking sequence (650 bp).
[2] Gene-specific DNA probe CH19 PGK is a 2.0 kb fragment cloned at EcoRI site in the vector lambda (Korneluk-1987)."

REF

IDN,MEB,FUN "Chen &: Fertil Steril, 27, 699-701, 1976
LOC,MOL "Gartler SM &: Somat Cell Mol Genet, 12, 395-401, 1986
LOC,MOL "Gartler SM &: CCG, 40, (HGM8), 635-636, 1985
PRO,EVO,FAG,EXP "Korneluk &: CCG, 46, (HGM9), 641, 1987
GEN,SEQ,EXP,EAG "McGarry JR, Thomas: Nature, 326, (2 Apr), 501-505, 1987
PRO,CLO,FAG "Michelson AM &: PNAS, 80, 472-476, 1983
PRO,CLO,FAG "Singer-Sam J &: PNAS, 80, 802-806, 1983
PRO,CLO,FAG "Szabo P &: PNAS, 81, 3167-3169, 1984
LOC,MOL "Willard HF &: Hum Genet, 71, N2, 138-143, 1985

KEY

sex, glyc

CLA

coding, basic

LOC

19 p13.3

MIM

MIM: 172270

EZN

ENZYME: 2.7.2.3

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