Gene: [19q132/PVR] poliovirus receptor (sensitivity); poliomyelitis infection, susceptibility to;
|
FUN |
Nevertheless this marker has been characterized adequately, endogenous functions of the protein are yet unknown." |
|
MOP |
[1] Poliovirus receptor belongs to the superfamily of immunoglobulin-like
peptides and has the characteristic structure that is common for these
peptides: the leader peptide, three extracellular Ig-like genes, the
transmembrane domain, and the short variable cytoplasmic domain
(Mendelsohn-1989).
[2] It is the poliovirus-specific receptor located on the cell membrane external surface and playing the key role in susceptibility to poliomyelytis that is supposed to be the product of PVS gene. Monoclonal antibodies to the receptor part of this receptor are obtained (D171; Mendehlsohn-1986)." |
|
TIS |
Using polyclonal antisera, Freistadt-1990 demonstrated that the poliovirus receptor and poliovirus receptor-like proteins are expressed not only in brain tissues but also in liver, kidney, and intestine. The spectrum of the poliovirus receptor-like protein expression is tissue-specific." |
|
FAG |
Two poliovirus receptor related genes have been mapped: GEM:11q2/PVRL1 and GEM:19q13/PVRL2." |
|
REF |
HIS,MEB "Bachtold &: Virology, 4, 582-589, 1957 LOC,CYG "Belehradek, Barski: CR Acad Sci Paris, 269, 672-675, 1969 LOC,LIN,CYG "Brook &: CCG, 46, (HGM9), 587, 1987 LOC,CYG "Couillin &: CCG, 46, (HGM9), 599, 1987 LOC,CYG,FAG,EVO "Couillin &: Pathol Biol, 24, 195-203, 1976 EXP,REL,TIS "Freistadt &: Mol Cell Biol, 10, N11, 5700-5706, 1990 HIS,MEB "Holland &: J Exp Med, 110, 65-80, 1959 LIN "Kaneda Y &: PNAS, 81, 3158-3162, 1984 MEB,FAG "Krah, Crowell: Virology, 118, 148-156, 1982 HIS,MEB "McLaren &: J Exp Med, 109, 475-485, 1959 CLO,COD,SEQ,EXP,EVO "Mendelsohn CL &: Cell, 56, 855-865, 1989 FUN,EXP "Mendelsohn CL &: PNAS, 83, N20, 7845-7849, 1986 LOC,CYG "Miller &: Cell, 1, 167-174, 1974 LOC,CYG "Schonk D &: CCG, 54, 15-19, 1990 LOC,CYG "Siddique T &: Genomics, 3, N2, 156-160, 1988 LOC,CYG "Siddique T &: CCG, 46, (HGM9), 692, 1987 LOC,CYG "Siddique T &: CCG, 40, (HGM8), 745, 1985 LOC,CYG "Trask B &: Genomics, 15, 133-145, 1993 |
|
KEY |
vir, mem, recp, neu, img |
|
CLA |
coding, basic |
|
LOC |
19 q13.2 |
|
MIM |
MIM: 173850 |
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