Gene: [19q134/LAIR1] leukocyte-associated immunoglobulin-like receptor 1;
|
COM |
The LAIR1 gene was mapped to Chr 19q13.4 by FISH (Meyaard-1997). |
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SUM |
LAIR1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR1 recruits SHP-1 (GEM:12p13/PTPN6) and SHP-2 (GEM:12q241/PTPN11) phosphatases upon activation, and cross-linking of the LAIR1 antigen on natural killer (NK) cells results in strong inhibition of NK-cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize HLA class I molecules (FAM:MHC1/06p2133) and thus represents a novel HLAI-independent mechanism of NK cell regulation (Meyaard-1997)." |
|
REL |
GEM:00.0/LAIR2; GEM:19q134/KIR2DL1. |
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REF |
COD,SEQ,LOC,EXP,FUN "Meyaard L &: Immunity, 7, 283-290, 1997 |
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KEY |
recp, imm, img |
|
CLA |
coding, basic |
|
LOC |
19 q13.4 |
|
MIM |
MIM: 602992 |
