Gene: [19q134/PTPRH] protein tyrosine phosphatase, receptor type, H;
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SUM |
[1] PTPRH is a human transmembrane-type protein tyrosine phosphatase that
is abundant in colon and pancreatic cancer cell lines.
[2] Predicted 1,118-amino acid PTPRH protein that has a putative 25-amino acid signal peptide, a 728-amino acid extracellular domain containing 8 fibronectin type III-like repeats, and a 340-amino acid cytoplasmic region containing the conserved PTP domain. PTPRH is structurally similar to PTPRB (GEM:12q/PTPRB), suggesting that they represent a subfamily of transmembrane-type PTPs (Matozaki-1994). [3] Normal colon tissue or adenomas with mild dysplasia showed no detectable expression of PTPRH. In contrast, 2 of 17 adenomas with moderate or severe dysplasia and 19 of 48 (40%) adenocarcinomas expressed PTPRH (Seo-1997)." |
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REF |
COD,SEQ,LOC "Matozaki T &: JBC, 269, 2075-2081, 1994 EXP,ASS "Seo Y &: BBRC, 231, 705-711, 1997 |
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KEY |
pep, recp, mem, onc |
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CLA |
coding, basic |
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LOC |
19 q13.4 |
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MIM |
MIM: 602510 |
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EZN |
ENZYME: 3.1.3.48 |
