Gene: [19q1/CCNE] cyclin E (G1/S-specific);
|
FUN |
Timing of the mRNA levels suggests that cyclin E plays a role in either the G1/S phase transition or in S phase. So cyclin E might activate the kinase at the beginning of S phase. It can interact with the cdc28 protein to perform its function." |
|
MOP |
Cyclin E do not contain 'mitotic destruction motif'. However this protein contain PEST sequences, which have been suggested to target proteins for rapid (and constitutive) degradation (Rogers-1986), near the carboxyl terminus (PEST-FIND score +1)." |
|
EXP |
Cyclin E mRNA accumulation was dramatically periodic through the cell cycle, peaking in late G1 near the G1/S phase transition." |
|
EVO |
Cyclin E share 58% similarity to human cyclin A vs. 49% similarity to yeast Cln 3 in the most conserved region (including most of the cyclin box)." |
|
REF |
LOC "Demetrick DJ &: CCG, 69, 190-192, 1995 MOP,EVO,EAG "see GEM:05q1/CCNB1 |
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KEY |
nucm, onc, repr |
|
CLA |
coding, basic |
|
LOC |
19 q12-13 |
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MIM |
MIM: 123837 |
