Gene: [21q2212/CBR1] carbonyl reductase 1 (NADPH) (EC:1.1.1.184); prostaglandin-E2 9-reductase (EC:1.1.1.189); hydroxyprostaglandin dehydrogenase 15- (NADP+) (EC:1.1.1.197);
COM | McInnis-1993 assigned carbonyl reductase to Chr 21q22.3. Lemieux-1993 refined the location to Chr 21q22.12 by fluorescence in situ hybridization." |
FUN | EC:1.1.1.184. Systematic name: secondary-alcohol:NADP(+) oxidoreductase. The catalyzed reaction: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol." |
REL | GEM:00.0/CBR3. |
REF | POL,LOC
"Avramopoulos D &: Genomics, 15, 98-102, 1993 POL,LOC,LIN "Avramopoulos D &: Genomics, 13, N2, 447-448, 1992 MAP "Chumakov I &: Nature, 359, N6394, 380-387, 1992 FUN "Forrest GL &: BBA, 1048, N2-3, 149-155, 1990 LOC "Lemieux N &: Genomics, 15, N1, 169-172, 1993 LOC,MAP "McInnis MG &: Genomics, 16, N3, 562-571, 1993 |
SWI | SWISSPROT: P16152 |
KEY | lip |
CLA | coding, basic |
LOC | 21 q22.12 |
MIM | MIM: 114830 |
EZN | ENZYME: 1.1.1.184 |
