Gene: [22q111/IGLV1] immunoglobulin lambda subunit, variable region 1; amyloidosis idiopathic (primary)?;
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MOP |
VAR peptides of the immunoglobulin lambda chain are found as sonstituents of so called fibrillar proteins of amyloid, the principal pathogenic marker of primary systemic and myeloma-associated amyloidoses. The pathogenesis of this pathologies remains for most part unclear." |
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REF |
PAT,MOP,PEP "Fykse &: Biochem J, 256, 973-980, 1988 PAT,MOP,PEP "Glenner GG: New Engl J Med, 302, 1283-1292, 1980a PAT,MOP,PEP "Glenner GG: New Engl J Med, 302, 1333-1343, 1980b PAT,MOP,PEP "Husby, Sletten: Scand J Immunol, 23, 253-265, 1986 CLO,PRO,LOC "see FAM:IGL/22q11 & FAM:IGLCJ/22q1121 |
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KEY |
imm, img |
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CLA |
coding, basic |
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LOC |
22 q11.1 |
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MIM |
MIM: 147240 |
