Gene: [22q112/ADORA2A] adenosine A2a receptor; [ADORA2 RDC8 ]
|
COM |
Previously ADORA2/ADORA2A has been mapped to Chr 11q11-13 (by in situ hybridisation; Libert-1991; Szepetowski-1993). Later Libert et al. had verified the sequences of the clones used as probes in their localization study and concluded that their probe was not ADORA2. MacCollin-1994 located ADORA2 to Chr 22 based upon both analysis of cosmid clones from Chr 22 library and by Southern hybridization with a comprehensive somatic cell hybrid panel. By FISH Le-1996 localized the ADORA2A gene on Chr 22q11.2" |
|
FUN |
The adenosine receptors regulate cardiac rate, contractility, release of neurotransmitters, renal and other functions." |
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REF |
MOP,EXP "Furlong TJ &: Mol Brain Res, 15, N1-2, 62-66, 1992 LOC "Le F &: BBRC, 223, N2, 461-467, 1996 HIS,COM,FAG "Libert F &: Genomics, 11, 225-227, 1991 PRO,COD "Libert F &: Science, 244, 569-572, 1989 PRO,LOC,EVO "MacCollin M &: Genomics, 20, 332-333, 1994 LIN,COM,HIS "Szepetowski P &: Genomics, 16, 745-750, 1993 |
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KEY |
nucm, recp, mem, neu |
|
CLA |
coding, basic |
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LOC |
22 q11.2 |
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MIM |
MIM: 102776 |
|
SYN |
ADORA2 RDC8 |
