Gene superfamily: adenosine A receptor; (ARF1 ARF2 ARF3 ARF4 ARF4L ARF4P ARF5 ARF6 ARL1 ARL2 ARL3 ARL4 ARD1)
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SUM |
[1] ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding
proteins that enhance the enzymatic activities of phospholipase D (GEM:03q2/PLD1)
and cholera toxin ADP-ribosyltransferase. ARFs are essential and
ubiquitous
in eukaryotes, being involved in vesicular transport. The functions of
ARF proteins in membrane traffic and organelle integrity are intimately
tied to their reversible association with membranes and specific
interactions with membrane phospholipids. A common feature of these
functions is their regulation by the binding and hydrolysis of GTP
(Amor-1994).
[2] ARFs constitute 1 family of the RAS superfamily. Monomeric guanine nucleotide-binding proteins of the RAS superfamily function in a variety of cellular processes including signaling, growth, immunity, and protein transport." |
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REF |
MOP,PEP,EXP,FUN "Amor JC &: Nature, 372, 704-708, 1994 CLO,SEQ,EXP "Bobak DA &: PNAS, 86, 6101-6105, 1989 CLO,SEQ,EXP "Peng ZG &: BioFactors, 2, 45-49, 1989 |
