Gene: [CD8/02p12] antigen CD8 (cluster on chr 2); (CD8A CD8B1 CD8B2)
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MOP |
The thymocyte maturation antigen, CD8, is a heterodimer consisting of alpha and beta peptides." |
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FAG |
In human, one gene for alpha subunit (GEM:02p12/CD8A) and two for beta subunit (GEM:02p12/CD8B1 and GEM:02p12/CD8B2) have been found." |
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EAG |
In rodents, MHC(I)-dependent thymocyte maturation antigen (LY in mouse and OX8 in rat) is a heterodimer consisting of the peptide products of different genes, as is the case for human." |
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HIS |
Till 1988, it was assumed that the homologous human antigen, CD8, is, in contrast, a homodimer of the peptide product of a single gene. In 1988, three laboratories independently identified and cloned the gene for the second component of CD8 antigen of human thymocytes (GEM:02p12/CD8B1). Thus, this antigen is a heterodimer, as is the case for other mammals." |
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REL |
GEM:12p1/CD4; FAM:IMM/00.0. |
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REF |
LOC,MOL,POL "Bowcock AM &: NAR, 14, 7817, 1986 LOC,MOL,POL "Bruns G &: Hum Genet, 70, 311-314, 1985 REV,GEN,FAG "Littman DR: Annu Rev Immunol, 5, 561-584, 1987 LOC,MOL,POL "Sukhatme VP &: J Exp Med, 161, 429-434, 1985 FUN,EXP,MOU "Zamoyska, Parnes: EMBO J, 7, N8, 2359-2367, 1988 SEQ,EXP,MOP "see GEM:02p12/CD8A |
