Gene: [IGHV/14q3233] immunoglobulin, heavy chain, variable minigenes, I-VI classes; (IGHVP1 IGHVA1 IGHVB1 IGHVC1 IGHVD1 IGHVE1 IGHVF1)
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SUM |
[1] It is assumed that, in addition to ten CON and J genes, about
100-200 VAR minigenes (both coding and pseudogenes) are located in
subsegment 14q32.33, within a 2.5 Mb interval. On one hand, these
minigenes have the common evolutionary origing; but on the other hand,
they are numerous and have undergone the divergent evolution as to
their primary structure. Therefore, the minigenes are subdivided into
several homology groups, the intra-group similarity between copies is
greater than inter-group one. Six homology classes (I-VI) are
distinguished for VH minigenes. The pricise number of coding and
faulty (pseudogene) copies in each class is not determined yet,
however, the following numeric distribution among classes seems to be
credible: class I, at least 25; class II, at least 10; class III,
aboit 30; class IV, at least 10 minigenes; class V, three coding
genes; and class VI, one coding gene. In this case, it is difficult to
elaborate the gene denotation, since it would be reasonable to reflect
in the gene symbol both assignment to a homology group and the
minigene ordinal number within the group. To meet both conditions, the
GEM catalogue adopted the letter denotation for homology groups (A to
F). On the other hand, it is hardly reasonable to register each
indiviual gene, until there is enough information to individualize
each of many tens of them.
[2] VH minigenes belonging to A-E (I-V) homology groups are located within a 579 kb NotI fragment at the telomeric end of the whole IGH cluster, whereas VF1 (or V6) minigene flanks the distal end of the J-DIV minigene cluster, which precedes the bulk of VH genes; see also FAM:IGH/14q3233." |
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REF |
EXP,SEQ,EVO,MAF "Berman JE &: EMBO J, 7, N3, 727-738, 1988 EXP,SEQ,EVO,MAF "Eaton, Calame: PNAS, 84, N21, 7634-7638, 1987 LOC,LIN,POL,MOL "Hobart MJ &: Ann Hum Genet, 45, 331-335, 1981 EXP,SEQ,EVO,MAF "Hoch, Schaber: J Immunol, 139, N5, 1689-1693, 1987 EXP,SEQ,EVO,MAF "Humphries SE &: Nature, 331, 446-449, 1988 LOC,LIN,POL,MOL "Johnson MJ &: PNAS, 81, N24, 7840-7844, 1984 EXP,SEQ,EVO,MAF "Kodaira &: J Mol Biol, 190, 529-?, 1986 EXP,SEQ,EVO,MAF "Kokubu &: EMBO J, 7, N11, 3413-3422, 1988 EXP,SEQ,EVO,MAF "Lee &: J Mol Biol, 195, 761-?, 1987 EXP,SEQ,EVO,MAF "Matsuda F &: EMBO J, 7, 1047-?, 1988 LOC,LIN,POL,MOL "Pandey JP &: Nature, 286, 406-407, 1980 EXP,SEQ,EVO,MAF "Rechavi G &: PNAS, 80, 855-859, 1983 EXP,SEQ,EVO,MAF "Rechavi G &: PNAS, 79, (Jul), 4405-4409, 1982 EXP,SEQ,EVO,MAF "Schroeder &: Science, 238, 791-?, 1987 EXP,SEQ,EVO,MAF "Shen A &: PNAS, 84, N23, 8563-8567, 1987 EXP,SEQ,EVO,MAF "Sims &: Science, 216, 309-311, 1982 EXP,SEQ,EVO,MAF "Takahashi N &: PNAS, 81, (Aug), 5194-5198, 1984 EXP,SEQ,EVO,MAF "Taussig MJ: J Immunogenet, 14, 179-188, 1987 EXP,SEQ,EVO,MAF "van Dijk &: J Immunol, 142, N7, 2547-2554, 1989 POL,MOL,MAF "Walter MA, Cox: AJHG, 42, 446-451, 1988 POL,MOL,MAF "Walter MA &: NAR, 15, N11, 4697, 1987 LOC,LIN,POL,MOL "Wang &: Science, 200, 327-329, 1978 |
