Gene: [MHC2/06p2133] major histocompatibility complex, class II polypeptides; (HLADRA HLADRB1 HLADRB1L HLADRB2 HLADRB2P HLADRB3 HLADRB4 HLADRB5 HLADRB6 HLADRB7 HLADRB8 HLADRB9 HLADMA HLADMB HLADQA1 HLADQB1 HLADVB HLADQA2 HLADQB2 HLADQB3 HLADOB HLADNA HLADPA1 HLADPB1 HLADPAP HLADPB2)
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SUM |
The MHC2 (HLA-D) gene products play a central role in the immune response by presenting exogenous peptides to CD4(+)-T-lymphocytes. In man, six different MHC2-subfamilies have been identified. With the exception of DN and DO all MHC2-subfamilies consist of one or more alpha and beta chains, which are highly polymorphed (except for DRA and DPA1) and expressed as heterodimers." |
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GEN |
On the basis of comparison of HLA-D gene organizations it was concluded that all alpha genes are composed of 5 exons and all beta genes of 6 exons, and that the intron/exon boundary classes of exons 1-4 in alpha genes and exons 1-5 in beta genes are 100% conserved. Only the last boundary class, which falls within the cytoplasmic domain, appears to be variable (Radley-1994)." |
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REF |
PRO,POL,LIN,STR,EXP "Begovich AB &: J Immunol, 148, N1, 249-258, 1992 REV,FUN,EXP,LIN "Neefjes JJ, Momburg F: Curr Opin Immunol, 5, 27-34, 1993 GEN,SEQ,EVO "Radley E &: JBC, 269, 18834-18838, 1994 ENG,EXP "Zwirner &: J Immunol, 148, N1, 272-276, 1992 |
