Gene: [RCA/01q32] complement activation regulator proteins; (CR1 CR2 C4BPA C4BPAL1 C4BPAL2 C4BPB DAF HF1 HFL3 HF2 MCP MCPL)

MAG

According to Heine-Suner-1997, the most likely gene order on the Chr 1q32 is as follows: See GEM:01q32/PFKFB2; GEM:01q32/SRP72."

SUM

Genes for six RCA factors (CR1, CR2, C4BP, DAF, HF, MCP) are located in Chr 1q32. They constitute the so called linkage group. All the RCA proteins contain a relatively conservative repeat (about 60 amino acid residues), SCR (Short Consensus Repeat): CR1 contains up to 30 SCRs; HF, 20 SCRs; CR2, 15-16 SCRs; C4BF, 8 SCRs; DAF and MCP, 4 SCRs each. Other complement components (B, C1R, C1S, and C2), as well as a number of other proteins (coagulation factor XIII beta peptide, receptor for interleukin 2, and beta-2-glycoprotein 1) also contain the SCR modules."

REF

LOC,MAG "Heine-Suner D &: Immunogenetics, 45, N6, 422-427, 1997
LOC,PRO "Hing &: Ann Hum Genet, 52, 117-122, 1988
LOC,LIN,MAP "Pardo-Manuel F &: PNAS, 87, N12, 4529-4532, 1990
LOC,LIN,MAF "Rey-Campos J &: J Exp Med, 167, 664-669, 1988
LOC,LIN,MAF "Rey-Campos J &: J Exp Med, 166, 246-252, 1987
FAG,MAP "Rodriguez de Cordoba S, Rubinstein: Immunogenetics, 25, 267-268, 1986a
FAG,MAP "Rodriguez de Cordoba S, Rubinstein: J Exp Med, 164, N4, 1274-1283, 1986b
LOC,LIN "Rodriguez de Cordoba S &: J Exp Med, 161, 1189-1195, 1985
LOC,LIN "Rodriguez de Cordoba S &: PNAS, 81, 7890-7892, 1984
GEN,SEQ,LOC "Wong WW &: J Exp Med, 169, 847-863, 1989