Gene family: ubiquitin polyproteins gene family (genes and pseudogenes); (UBA1 UBA2 UBB UBBP1 UBBP2 UBBP3 UBBP4 UBC)

PAT

 In the clinical aspect, of interest is the report of Lowe-1988, which demonstrated that the 'ubiquitinization' of aggregating intermediate filaments (particularly neurofilaments) underlies the formation of various cell inclusions (Levi, Pick, and Mallori bodies; Alzheimer and Rosenthal tangles) in such diseases as Parkinson's disease, Pick's and Alzheimer's presenile dementions, alcoholic cirrhosis, thus being probably an important pathogenetic factor for these pathologies."

REF

 FUN,PEP,PAT "Ananthan &: Science, 232, 522-524, 1986
FUN,PEP,PAT "Audhya, Goldstein: Methods Enzymol, 116, 279-291, 1985
FUN,PEP,PAT "Busch H: Methods Enzymol, 106, 238-262, 1984
ENG,MUT,MOP "Ecker &: JBC, 262, N29, 14213-14221, 1987
FUN,PEP,PAT "Goldknopf, Busch: PNAS, 74, 5492-5495, 1977
FUN,PEP,PAT "Haas, Bright: JBC, 260, 12464-12473, 1985
REV,FUN,EVO "Hershko, Ciechanover: Prog NAR, 33, 19-56, 1987
FUN,PEP,PAT "Lowe &: J Pathol, 155, 9-15, 1988
FUN,PEP,PAT "Matsui &: PNAS, 76, 6386-6390, 1979
FUN,PEP,PAT "Mory &: Science, 235, 1641-1644, 1987
REV,GEN "Schlesinger MJ, Bond U: Oxford Surv Eukar Genes, 4, 77-91, 1987
FUN,PEP,PAT "Siegelman &: Science, 231, 823-829, 1986
CLO,SEQ,MOP,FAG "Wiborg O &: EMBO J, 4, N3, 755-759, 1985
FUN,PEP,PAT "Wilkinson, Mayer: Arch Biochem Biophys, 250, 390-399, 1986