Role of Transcription Factor NFAT in the Immune Response
The molecular mechanisms of activation of nuclear factor NFAT in cells of limphoidmyeloid complex are considered. The role of NFAT family proteins are discussed in transcription of genes whose products are involved in induction and/or regulation of the immune response. Based on the transcripthion activity of NFAT, attemps are made to explain the changes in immune state of an organism in case of deficiency or blockade of this factor.
