Рис. F 11 seq
Нуклеотидная и аминокислотная последовательности
гена фактора XI (Factor XI) человека
ATG ATT TTC TTA TAT CAA GTG GTA CAT TTC ATT TTA TTT ACT TCA
met ile phe leu tyr gln val val his phe ile leu phe thr ser 15
GTT TCT GGT GAA TGT GTG ACT CAG TTG TTG AAG GAC ACC TGC TTT
val ser gly glu cys val thr gln leu leu lys asp thr cys phe 30
GAA GGA GGG GAC ATT ACT ACG GTC TTC ACA CCA AGC GCC AAG TAC
glu gly gly asp ile thr thr val phe thr pro ser ala lys tyr 45
TGC CAG GTA GTC TGC ACT TAC CAC CCA AGA TGT TTA CTC TTC ACT
cys gln val val cys thr tyr his pro arg cys leu leu phe thr 60
TTC ACG GCG GAA TCA CCA TCT GAG GAT CCC ACC CGA TGG TTT ACT
phe thr ala glu ser pro ser glu asp pro thr arg trp phe thr 75
TGT GTC CTG AAA GAC AGT GTT ACA GAA ACA CTG CCA AGA GTG AAT
cys val leu lys asp ser val thr glu thr leu pro arg val asn 90
AGG ACA GCA GCG ATT TCT GGG TAT TCT TTC AAG CAA TGC TCA CAC
arg thr ala ala ile ser gly tyr ser phe lys gln cys ser his 105
CAA ATA AGC GCT TGC AAC AAA GAC ATT TAT GTG GAC CTA GAC ATG
gln ile ser ala cys asn lys asp ile tyr val asp leu asp met 120
AAG GGC ATA AAC TAT AAC AGC TCA GTT GCC AAG AGT GCT CAA GAA
lys gly ile asn tyr asn ser ser val ala lys ser ala gln glu 135
TGC CAA GAA AGA TGC ACG GAT GAC GTC CAC TGC CAC TTT TTC ACG
cys gln glu arg cys thr asp asp val his cys his phe phe thr 150
TAC GCC ACA AGG CAG TTT CCC AGC CTG GAG CAT CGT AAC ATT TGT
tyr ala thr arg gln phe pro ser leu glu his arg asn ile cys 165
CTA CTG AAG CAC ACC CAA ACA GGG ACA CCA ACC AGA ATA ACG AAG
leu leu lys his thr gln thr gly thr pro thr arg ile thr lys 180
CTC GAT AAA GTG GTG TCT GGA TTT TCA CTG AAA TCC TGT GCA CTT
leu asp lys val val ser gly phe ser leu lys ser cys ala leu 195
TCT AAT CTG GCT TGT ATT AGG GAC ATT TTC CCT AAT ACG GTG TTT
ser asn leu ala cys ile arg asp ile phe pro asn the val phe 210
GCA GAC AGC AAC ATC GAC AGT GTC ATG GCT CCC GAT GCT TTT GTC
ala asp ser asn ile asp ser val met ala pro asp ala phe val 225
TGT GGC CGA ATC TGC ACT CAT CAT CCC GGT TGC TTG TTT TTT ACC
cys gly arg ile cys thr his his pro gly cys leu phe phe thr 240
TTC TTT TCC CAG GAA TGG CCC AAA GAA TCT CAA AGA AAT CTT TGT
phe phe ser gln glu trp pro lys glu ser gln arg asn leu cys 255
CTC CTT AAA ACA TCT GAG AGT GGA TTG CCC AGT ACA CGC ATT AAA
leu leu lys thr ser glu ser gly leu pro ser thr arg ile lys 270
AAG AGC AAA GCT CTT TCT GGT TTC AGT CTA CAA AGC TGC AGG CAC
lys ser lys ala leu ser gly phe ser leu gln ser cys arg his 285
AGC ATC CCA GTG TTC TGC CAT TCT TCA TTT TAC CAT GAC ACT GAT
ser ile pro val phe cys his ser ser phe tyr his asp thr asp 300
TTC TTG GGA GAA GAA CTG GAT ATT GTT GCT GCA AAA AGT CAC GAG
phe leu gly glu glu leu asp ile val ala ala lys ser his glu 315
GCC TGC CAG AAA CTG TGC ACC AAT GCC GTC CGC TGC CAG TTT TTT
ala cys gln lys leu cys thr asn ala val arg cys gln phe phe 330
ACC TAT ACC CCA GCC CAA GCA TCC TGC AAC GAA GGG AAG GGC AAG
thr tyr thr pro ala gln ala ser cys asn glu gly lys gly lys 345
TGT TAC TTA AAG CTT TCT TCA AAC GGA TCT CCA ACT AAA ATA CTT
cys tyr leu lys leu ser ser asn gly ser pro thr lys ile leu 360
CAC GGG AGA GGA GGC ATC TCT GGA TAC ACA TTA AGG TTG TGT AAA
his gly arg gly gly ile ser gly tyr thr leu arg leu cys lys 375
ATG GAT AAT GAG TGT ACC ACC AAA ATC AAG CCC AGG ATC GTT GGA
met asp asn glu cys thr thr lys ile lys pro arg ile val gly 390
GGA ACT GCG TCT GTT CGT GGT GAG TGG CCG TGG CAG GTG ACC CTG
gly thr ala ser val arg gly glu trp pro trp gln val thr leu 405
CAC ACA ACC TCA CCC ACT CAG AGA CAC CTG TGT GGA GGC TCC ATC
his thr thr ser pro thr gln arg his leu cys gly gly ser ile 420
ATT GGA AAC CAG TGG ATA TTA ACA GCC GCT CAC TGT TTC TAT GGG
ile gly asn gln trp ile leu thr ala ala his cys phe tyr gly 435
GTA GAG TCA CCT AAG ATT TTG CGT GTC TAC AGT GGC ATT TTA AAT
val glu ser pro lys ile leu arg val tyr ser gly ile leu asn 450
CAA TCT GAA ATA AAA GAG GAC ACA TCT TTC TTT GGG GTT CAA GAA
gln ser glu ile lys glu asp thr ser phe phe gly val gln glu 465
ATA ATA ATC CAT GAT CAG TAT AAA ATG GCA GAA AGC GGG TAT GAT
ile ile ile his asp gln tyr lys met ala glu ser gly tyr asp 480
ATT GCC TTG TTG AAA CTG GAA ACC ACA GTG AAT TAC ACA GAT TCT
ile ala leu leu lys leu glu thr thr val asn tyr thr asp ser 495
CAA CGA CCC ATA TGC CTG CCT TCC AAA GGA GAT AGA AAT GTA ATA
gln arg pro ile cys leu pro ser lys gly asp arg asn val ile 510
TAC ACT GAT TGC TGG GTG ACT GGA TGG GGG TAC AGA AAA CTA AGA
tyr thr asp cys trp val thr gly trp gly tyr arg lys leu arg 525
GAC AAA ATA CAA AAT ACT CTC CAG AAA GCC AAG ATA CCC TTA GTG
asp lys ile gln asn thr leu gln lys ala lys ile pro leu val 540
ACC AAC GAA GAG TGC CAG AAG AGA TAC AGA GGA CAT AAA ATA ACC
thr asn glu glu cys gln lys arg tyr arg gly his lys ile thr 555
CAT AAG ATG ATC TGT GCC GGC TAC AGG GAA GGA GGG AAG GAC GCT
his lys met ile cys ala gly tyr arg glu gly gly lys asp ala 570
TGC AAG GGA GAT TCG GGA GGC CCT CTG TCC TGC AAA CAC AAT GAG
cys lys gly asp ser gly gly pro leu ser cys lys his asn glu 585
GTC TGG CAT CTG GTA GGC ATC ACG AGC TGG GGC GAA GGC TGT GCT
val trp his leu val gly ile thr ser trp gly glu gly cys ala 600
CAA AGG GAG CGG CCA GGT GTT TAC ACC AAC GTG GTC GAG TAC GTG
gln arg glu arg pro gly val tyr thr asn val val glu tyr val 615
GAC TGG ATT CTG GAG AAA ACT CAA GCA GTG TGA
asp trp ile leu glu lys thr gln ala val ter
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