Рис. F 12 seq
Нуклеотидная и аминокислотная последовательности гена фактора XII (Factor XII) человека
-19
ATG AGG GCT CTG CTG CTC CTG GGG TTC CTG CTG GTG AGC TTG GAG
met arg ala leu leu leu leu gly phe leu leu val ser leu glu 15
+1
TCA ACA CTT TCG ATT CCA CCT TGG GAA GCC CCC AAG GAG CAT AAG
ser thr leu ser ile pro pro trp glu ala pro lys glu his lys 30
TAC AAA GCT GAA GAG CAC ACA GTC GTT CTC ACT GTC ACC GGG GAG
tyr lys ala glu glu his thr val val leu thr val thr gly glu 45
CCC TGC CAC TTC CCC TTC CAG TAC CAC CGG CAG CTG TAC CAC AAA
pro cys his phe pro phe gln tyr his arg gln leu tyr his lys 60
TGT ACC CAC AAG GGC CGG CCA GGC CCT CAG CCC TGG TGT GCT ACC
cys thr his lys gly arg pro gly pro gln pro trp cys ala thr 75
ACC CCC AAC TTT GAT CAG GAC CAG CGA TGG GGA TAC TGT TTG GAG
thr pro asn phe asp gln asp gln arg trp gly tyr cys leu glu 90
CCC AAG AAA GTG AAA GAC CAC TGC AGC AAA CAC AGC CCC TGC CAG
pro lys lys val lys asp his cys ser lys his ser pro cys gln 105
AAA GGA GGG ACC TGT GTG AAC ATG CCA AGC GGC CCC CAC TGT CTC
lys gly gly thr cys val asn met pro ser gly pro his cys leu 120
TGT CCA CAA CAC CTC ACT GGA AAC CAC TGC CAG AAA GAG AAG TGC
cys pro gln his leu thr gly asn his cys gln lys glu lys cys 135
TTT GAG CCT CAG CTT CTC CGG TTT TTC CAC AAG AAT GAG ATA TGG
phe glu pro gln leu leu arg phe phe his lys asn glu ile trp 150
TAT AGA ACT GAG CAA GCA GCT GTG GCC AGA TGC CAG TGC AAG GGT
tyr arg trp glu gln ala ala val ala arg cys gln cys lys gly 165
CCT GAT GCC CAC TGC CAG CGG CTG GCC AGC CAG GCC TGC CGC ACC
pro asp ala his cys gln arg leu ala ser gln ala cys arg thr 180
AAC CCG TGC CTC CAT GGG GGT CGC TGC CTA GAG GTG GAG GGC CAC
asn pro cys leu his gly gly arg cys leu glu val glu gly his 195
CGC CTG TGC CAC TGC CCG GTG GGC TAC ACC GGA CCC TTC TGC GAC
arg leu cys his cys pro val gly tyr thr gly pro phe cys asp 210
GTG GAC ACC AAG GCA AGC TGC TAT GAT GGC CGC GGG CTC AGC TAC
val asp thr lys ala ser cys tyr asp gly arg gly leu ser tyr 225
CGC GGC CTG GCC AGG ACC ACG CTC TCG GGT GCG CCC TGT CAG CCG
arg gly leu ala arg thr thr leu ser gly ala pro cys gln pro 240
TGG GCC TCG GAG GCC ACC TAC CGG AAC GTG ACT GCC GAG CAA GCG
trp ala ser glu ala thr tyr arg asn val thr ala glu gln ala 255
CGG AAC TGG GGA CTG GGC GGC CAC GCC TTC TGC CGG AAC CCG GAC
arg asn trp gly leu gly gly his ala phe cys arg asn pro asp 270
AAC GAC ATC CGC CCG TGG TGC TTC GTG CTG AAC CGC GAC CGG CTG
asn asp ile arg pro trp cys phe val leu asn arg asp arg leu 285
AGC TGG GAG TAC TGC GAC CTG GCA CAG TGC CAG ACC CCA ACC CAG
ser trp glu tyr cys asp leu ala gln cys gln thr pro thr gln 300
GCG GCG CCT CCG ACC CCG GTG TCC CCT AGG CTT CAT GTC CCA CTC
ala ala pro pro thr pro val ser pro arg leu his val pro leu 315
ATG CCC GCG CAG CCG GCA CCG CCG AAG CCT CAG CCC ACG ACC CGG
met pro ala gln pro ala pro pro lys pro gln pro thr thr arg 330
ACC CCG CCT CAG TCC CAG ACC CCG GGA GCC TTG CCG GCG AAG CGG
thr pro pro gln ser gln thr pro gly ala leu pro ala lys arg 345
GAG CAG CCG CCT TCC CTG ACC AGG AAC GGC CCA CTG AGC TGC GGG
glu gln pro pro ser leu thr arg asn gly pro leu ser cys gly 360
CAG CGG CTC CGC AAG AGT CTG TCT TCG ATG ACC CGC GTC GTT GGC
gln arg leu arg lys ser leu ser ser met thr arg val val gly 375
GGG CTG GTG GCG CTA CGC GGG GCG CAC CCC TAC ATC GCC GCG CTG
gly leu val ala leu arg gly ala his pro tyr ile ala ala leu 390
TAC TGG GGC CAC AGT TTC TGC GCC GGC AGC CTC ATC GCC CCC TGC
tyr trp gly his ser phe cys ala gly ser leu ile ala pro cys 405
TGG GTG CTG ACG GCC GCT CAC TGC CTG CAG GAC CGG CCC GCA CCC
trp val leu thr ala ala his cys leu gln asp arg pro ala pro 420
GAG GAT CTG ACG GTG GTG CTC GGC CAG GAA CGC CGT AAC CAC AGC
glu asp leu thr val val leu gly gln glu arg arg asn his ser 435
TGT GAG CCG TGC CAG ACG TTG GCC GTG CGC TCC TAC CGC TTG CAC
cys glu pro cys gln thr leu ala val arg ser tyr arg leu his 450
GAG GCC TTC TCG CCC GTC AGC TAC CAG CAC GAC CTG GCT CTG TTG
glu ala phe ser pro val ser tyr gln his asp leu ala leu leu 465
CGC CTT CAG GAG GAT GCG GAC GGC AGC TGC GCG CTC CTG TCG CCT
arg leu gln glu asp ala asp gly ser cys ala leu leu ser pro 480
TAC GTT CAG CCG GTG TGC CTG CCA AGC GGC GCC GCG CGA CCC TCC
tyr val gln pro val cys leu pro ser gly ala ala arg pro ser 495
GAG ACC ACG CTC TGC CAG GTG GCC GGC TGG GGC CAC CAG TTC GAG
glu thr thr leu cys gln val ala gly trp gly his gln phe glu 510
GGG GCG GAG GAA TAT GCC AGC TTC CTG CAG GAG GCG CAG GTA CCG
gly ala glu glu tyr ala ser phe leu gln glu ala gln val pro 525
TTC CTC TCC CTG GAG CGC TGC TCA GCC CCG GAC GTG CAC GGA TCC
phe leu ser leu glu arg cys ser ala pro asp val his gly ser 540
TCC ATC CTC CCC GGC ATG CTC TGC GCA GGG TTC CTC GAG GGC GGC
ser ile leu pro gly met leu cys ala gly phe leu glu gly gly 555
ACC GAT GCG TGC CAG GGT GAT TCC GGA GGC CCG CTG GTG TGT GAG
thr asp ala cys gln gly asp ser gly gly pro leu val cys glu 570
GAC CAA GCT GCA GAG CGC CGG CTC ACC CTG CAA GGC ATC ATC AGC
asp gln ala ala glu arg arg leu thr leu gln gly ile ile ser 585
TGG GGA TCG GGC TGT GGT GAC CGC AAC AAG CCA GGC GTC TAC ACC
trp gly ser gly cys gly asp arg asn lys pro gly val tyr thr 600
GAT GTG GCC TAC TAC CTG GCC TGG ATC CGG GAG CAC ACC GTT TCC
asp val ala tyr tyr leu ala trp ile arg glu his thr val ser 615
TGA
ter
