Рис. F 5 seq

         Нуклеотидная и аминокислотная последовательности
                      гена фактора коагуляции V (F V)
   -28
   ATG TTC CCA GGC TGC CCA CGC CTC TGG GTC CTG GTG GTC TTG GGC
   met phe pro gly cys pro arg leu trp val leu val val leu gly    15

   ACC AGC TGG GTA GGC TGG GGG AGC CAA GGG ACA GAA GCG GCA CAG
   trp ser trp val gly trp gly ser gln gly thr glu ala ala gln    30

   CTA AGG CAG TTC TAC GTG GCT GCT CAG GGC ATC AGT TGG AGC TAC
   leu arg glb phe tyr val ala ala gln gly ile ser trp ser tyr    45

   CGA CCT GAG CCC ACA AAC TCA AGT TTG AAT CTT TCT GTA ACT TCC
   arg pro glu pro thr asn ser ser leu asn leu ser val thr ser    60

   TTT AAG AAA ATT GTC TAC AGA GAG TAT GAA CCA TAT TTT AAG AAA
   phe lys lys ile val tyr arg glu tyr glu pro tyr phe lys lys    75

   GAA AAA CCA CAA TCT ACC ATT TCA GGA CTT CTT GGG CCT ACT TTA
   glu lys pro gln ser thr ile ser gly leu leu gly pro thr leu    90

   TAT GCT GAA GTC GGA GAC ATC ATA AAA GTT CAC TTT AAA AAT AAG
   tyr ala glu val gly asp ile ile lys val his phe lys asn lys   105

   GCA GAT AAG CCC TTG AGC ATC CAT CCT CAA GGA ATT AGG TAC AGT
   ala asp lys pro leu ser ile his pro gln gly ile arg tyr ser   120

   AAA TTA TCA GAA GGT GCT TCT TAC CTT GAC CAC ACA TTC CCT GCA
   lys leu ser glu gly ala ser tyr leu asp his thr phe pro ala   135

   GAG AAG ATG GAC GAC GCT GTG GCT CCA GGC CGA GAA TAC ACC TAT
   glu lys met asp asp ala val ala pro gly arg glu tyr thr tyr   150

   GAA TGG AGT ATC AGT GAG GAC AGT GGA CCC ACC CAT GAT GAC CCT
   glu trp ser ile ser glu asp ser gly pro thr his asp asp pro   165

   CCA TGC CTC ACA CAC ATC TAT TAC TCC CAT GAA AAT CTG ATC GAG
   pro cys leu thr his ile tyr tyr ser his glu asn leu ile glu   180

   GAT TTC AAC TCT GGG CTG ATT GGG CCC CTG CTT ATC TGT AAA AAA
   asp phe asn ser gly leu ile gly pro leu leu ile cys asn lys   195

   GGG ACC CTA ACT GAG GGT GGG ACA CAG AAG ACG TTT GAC AAG CAA
   gly thr leu thr glu gly gly thr gln lys thr phe asp lys gln   210

   ATC GTG CTA CTA TTT GCT GTG TTT GAT GAA AGC AAG AGC TGG AGC
   ile val leu leu phe ala val phe asp glu ser lys ser trp ser   225

   CAG TCA TCA TCC CTA ATG TAC ACA GTC AAT GGA TAT GTG AAT GGG
   gln ser ser ser leu met tyr thr val asn gly tyr val asn gly   240

   ACA ATG CCA GAT ATA ACA GTT TGT GCC CAT GAC CAC ATC AGC TGG
   thr met pro asp ile thr val cys ala his asp his ile ser trp   255

   CAT CTG CTG GGA ATG AGC TCG GGG CCA GAA TTA TTC TCC ATT CAT
   his leu leu gly met ser ser gly pro glu leu phe ser ile his   270

   TTC AAC GGC CAG GTC CTG GAG CAG AAC CAT CAT AAG GTC TCA GCC
   phe asn gly gln val leu glu gln asn his his lys val ser ala   285

   ATC ACC CTT GTC AGT GCT ACA TCC ACT ACC GCA AAT ATG ACT GTG
   ile thr leu val ser ala thr ser thr thr ala asn met thr val   300

   GGC CCA GAG GGA AAG TGG ATC ATA TCT TCT CTC ACC CCA AAA CAT
   gly pro glu gly lys trp ile ile ser ser leu thr pro lys his   315

   TTG CAA GCT GGG ATG CAG GCT TAC ATT GAC ATT AAA AAC TGC CCA
   leu gln ala gly met gln ala tyr ile asp ile lys asn cys pro   330

   AAG AAA ACC AGG AAT CTT AAG AAA ATA ACT CGT GAG CAG AGG CGG
   lys lys thr arg asn leu lys lys ile thr arg glu gln arg arg   345

   CAC ATG AAG AGG TGG GAA TAC TTC ATT GCT GCA GAG GAA GTC ATT
   his met lys arg trp glu tyr phe ile ala ala glu glu val ile   360

   TGG GAC TAT GCA CCT GTA ATA CCA GCG AAT ATG GAC AAA AAA TAC
   trp asp tyr ala phe val ile pro ala asn met asp lys lys tyr   375

   AGG TCT CAG CAT TTG GAT AAT TTC TCA AAC CAA ATT GGA AAA CAT
   arg ser gln his leu asp asn phe ser asn gln ile gly lys his   390

   TAT AAG AAA GTT ATG TAC ACA CAG TAC GAA GAT GAG TCC TTC ACC
   tyr lys lys val met tyr thr gln tyr glu asp glu ser phe tyr   405

   AAA CAT ACA GTG AAT CCC AAT ATG AAA GAA GAT GGG ATT TTG GGT
   lys his thr val asn pro asn met lys glu asp gly ile leu gly   420

   CCT ATT ATC AGA GCC CAG GTC AGA GAC ACA CTC AAA ATC GTG TTC
   pro ile ile arg ala gln val arg asp the leu lys ile val phe   435

   AAA AAT ATG GCC AGC CGC CCC TAT AGC ATT TAC CCT CAT GGA GTG
   lys asn met ala ser arg pro tyr ser ile tyr pro his gly val   450

   ACC TTC TCG CCT TAT GAA GAT GAA GTC AAC TCT TCT TTC ACC TCA
   thr phe ser pro tyr glu asp glu val asn ser ser phe thr ser   465

   GGC AGG AAC AAC ACC ATG ATC AGA GCA GTT CAA CCA GGG GAA ACC
   gly arg asn asn thr met ile arg ala val gln pro gly glu thr   480

   TAT ACT TAT AAG TGG AAC ATC TTA GAG TTT GAT GAA CCC ACA GAA
   tyr thr tyr lys trp asn ile leu glu phe asp glu pro thr glu   495

   AAT GAT GCC CAG TGC TTA ACA AGA CCA TAC TAC AGT GAC GTG GAC
   asn asp ala gln cys leu thr arg pro tyr tyr ser asp val asp   510

   ATC ATG AGA GAC ATC GCC TCT GGG CTA ATA GGA CTA CTT CTA ATC
   ile met arg asp ile ala ser gly leu ile gly leu leu leu ile   525

   TGT AAG AGC AGA TCC CTG GAC AGG CGA GGA ATA CAG AGG GCA GCA
   cys lys ser arg ser leu asp arg arg glu ile gln arg ala ala   540

   GAC ATC GAA CAG CAG GCT GTG TTT GCT GTG TTT GAT GAG AAC AAA
   asp ile glu gln gln ala val phe ala val phe asp glu asn lys   555

   AGC TGG TAC CTT GAG GAC AAC ATC AAC AAG TTT TGT GAA AAT CCT
   ser trp tyr leu glu asp asn ile asn lys phe cys glu asn pro   570

   GAT GAG GTG AAA CGT GAT GAC CCC AAG TTT TAT GAA TCA AAC ATC
   asp glu val lys arg asp asp pro lys phe tyr glu ser asn ile   595

   ATG AGC ACT ATC AAT GGC TAT GTG CCT GAG AGC ATA ACT ACT CTT
   met ser thr ile asn gly tyr val pro glu ser ile thr thr leu   610

   GGA TTC TGC TTT GAT GAC ACT GTC CAG TGG CAC TTC TGT AGT GTG
   gly phe cys [he asp asp thr val gln trp his phe cys ser val   625

   GGG ACC CAG AAT GAA ATT TTG ACC ATC CAC TTC ACT GGG CAC TCA
   gly thr gln asn glu ile leu thr ile his phe thr gly his ser   640

   TTC ATC TAT GGA AAG AGG CAT GAG GAC ACC TTG ACC CTC TTC CCC
   phe ile tyr gly lys arg his glu asp thr leu thr leu phe pro   655

   ATG CGT GGA GAA TCT GTG ACG GTC ACA ATG GAT AAT GTT GGA ACT
   met arg gly glu ser val thr val thr met asp asn val gly thr   680

   TGG ATG TTA ACT TCC ATG AAT TCT AGT CCA AGA AGC AAA AAG CTG
   trp met leu thr ser met asn ser ser pro arg ser lys lys leu   695

   AGG CTG AAA TTC AGG GAT GTT AAA TGT ATC CCA GAT GAT GAT GAA
   arg leu lys phe arg asp val lys cys ile pro asp asp asp glu   710

   GAC TCA TAT GAG ATT TTT GAA CCT CCA GAA TCT ACA GTC ATG GCT
   asp ser tyr glu ile phe glu pro pro glu ser thr val met ala   725

   ACA CGG AAA ATG CAT GAT CGT TTA GAA CCT GAA GAT GAA GAG AGT
   thr arg lys met his asp arg leu glu pro glu asp glu glu ser   740

   GAT GCT GAC TAT GAT TAC CAG AAC AGA CTG GCT GCA GCA TTA GGA
   asp ala asp tyr asp tyr gln asn arg leu ala ala ala leu gly   755

   ATT AGG TCA TTC CGA AAC TCA TCA TTG AAC CAG GAA GAA GAA GAG
   ile arg ser phe arg asn ser ser leu asn gln glu glu glu glu   770

   TTC AAT CTT ACT GCC CTA GCT CTG GAG AAT GGC ACT GAA TTC GTT
   phe asn leu thr ala leu ala leu glu gln gly thr glu phe val   785

   TCT TCG AAC ACA GAT ATA ATT GTT GGT TCA AAT TAT TCT TCC CCA
   ser ser asn thr asp ile ile val gly ser asn tyr ser ser pro   800

   AGT AAT ATT AGT AAG TTC ACT GTC AAT AAC CTT GCA GAA CCT CAG
   ser asn ile ser lys phe thr val asn asn leu ala glu pro gln   815

   AAA GCC CCT TCT CAC CAA CAA GCC ACC ACA GCT GGT TCC CCA CTG
   lys ala pro ser his gln gln ala thr thr ala gly ser pro leu   830

   AGA CAC CTC ATT GGC AAG AAC TCA GTT CTC AAT TCT TCC ACA GCA
   arg his leu ile gly lys asn ser val leu asn ser ser thr ala   845

   GAG CAT TCC AGC CCA TAT TCT GAA GAC CCT ATA GAG GAT CCT CTA
   glu his ser ser pro tyr ser glu asp pro ile glu asp pro leu   860

   CAG CCA GAT GTC ACA GGG ATA CGT CTA CTT TCA CTT GGT GCT GGA
   gln pro asp val thr gly ile arg leu leu ser leu gly ala gly   875

   GAA TTC AGA AGT CAA GAA CAT GCT AAG CGT AAG GGA CCC AAG GTA
   glu phe arg ser gln glu his ala lys arg lys gly pro lys val   890

   GAA AGA GAT CAA GCA GCA AAG CAC AGG TTC TCC TGG ATG AAA TTA
   glu arg asp gln ala ala lys his arg phe ser trp met lys leu   905

   CTA GCA CAT AAA GTT GGG AGA CAC CTA AGC CAA GAC ACT GGT TCT
   leu ala his lys val gly arg his leu ser gln asp thr gly ser   920

   CCT TCC GGA ATG AGG CCC TGG GAG GAC CTT CCT AGC CAA GAC ACT
   pro ser gly met arg pro trp glu asp leu pro ser gln asp thr   935

   GGT TCT CCT TCC AGA ATG AGG CCC TGG GAG GAC CCT CCT AGT GAT
   gly ser pro ser arg met arg pro trp glu asp pro pro ser asp   950

   CTG TTA CTC TTA AAA CAA AGT AAC TCA TCT AAG ATT TTG GTT GGG
   leu leu leu leu lys gln ser asn ser ser lys ile leu val gly   965

   AGA TGG CAT TTG GCT TCT GAG AAA GGT AGC TAT GAA ATA ATC CAA
   arg trp his leu ala ser glu lys gly ser tyr glu ile ile gln   980

   GAT ACT GAT GAA GAC ACA GCT GTT AAC AAT TGG CTG ATC AGC CCC
   asp thr asp glu asp thr ala val asn asn trp leu ile ser pro   995

   CAG AAT GCC TCA CGT GCT TGG GGA GAA AGC ACC CCT CTT GCC AAC
   gln asn ala ser arg ala trp gly glu ser thr pro leu ala asn  1100

   AAG CCT GGA AAG CAG AGT GGC CAC CCA AAG TTT CCT AGA GTT AGA
   lys pro gly lys gln ser gly his pro lys phe peo arg val arg  1115

   CAT AAA TCT CTA CAA GTA AGA CAG GAT GGA GGA AAG AGT AGA CTG
   his lys ser leu gln val arg gln asp gly gly lys ser arg leu  1130

   AAG AAA AGC CAG TTT CTC ATT AAG ACA CGA AAA AAG AAA AAA GAG
   lys lys ser gln phe leu ile lys thr arg lys lys lys lys glu  1145

   AAG CAC ACA CAC CAT GCT CCT TTA TCT CCG AGG ACC TTT CAC CCT
   lys his thr his his ala pro leu ser pro arg thr phe his pro  1160

   CTA AGA AGT GAA GCC TAC AAC ACA TTT TCA GAA AGA AGA CTT AAG
   leu arg ser glu ala tyr asn thr phe ser glu arg arg leu lys  1175

   CAT TCG TTG GTG CTT CAT AAA TCC AAT GAA ACA TCT CTT CCC ACA
   his ser leu val leu his lys ser asn glu thr ser leu pro thr  1190

   GAC CTC AAT CAG ACA TTG CCC TCT ATG GAT TTT GGC TGG ATA GCC
   asp leu asn gln thr leu pro ser met asp phe gly trp ile ala  2005

   TCA CTT CCT GAC CAT AAT CAG AAT TCC TCA AAT GAC ACT GGT CAG
   ser leu pro asp his asn gln asn ser ser asn asp thr gly gln  2020

   GCA AGC TGT CCT CCA GGT CTT TAT CAG ACA GTG CCC CCA GAG GAA
   ala ser cys pro pro gly leu tyr gln thr val pro pro glu glu  2035

   CAC TAT CAA ACA TTC CCC ATT CAA GAC CCT GAT CAA ATG CAC TCT
   his tyr gln thr phe pro ile gln asp pro asp gln met his ser  2050

   ACT TCA GAC CCC AGT CAC AGA TCC TCT TCT CCA GAG CTC AGT GAA
   thr ser asp pro ser his arf ser ser ser pro glu leu ser glu  2065

   ATG CTT GAG TAT GAC CGA AGT CAC AAG TCC TTC CCC ACA GAT ATA
   met leu glu tyr asp arg ser his lys ser phe pro thr asp ile  2080

   AGT CAA ATG TCC CCT TCC TCA GAA CAT GAA GTC TGG CAG ACA GTC
   ser gln met ser pro ser ser glu his glu val trp gln thr val  2095

   ATC TCT CCA GAC CTC AGC CAG GTG ACC CTC TCT CCA GAA CTC AGC
   ile ser pro asp leu ser gln val thr leu ser pro glu leu ser  2110

   CAG ACA AAC CTC TCT CCA GAC CTC AGC CAC ACG ACT CTC TCT CCA
   gln thr asn leu ser pro asp leu ser his thr thr leu ser pro  2125

   GAA CTC ATT CAG AGA AAC CTT TCC CCA GCC CTC GGT CAG ATG CCC
   glu leu ile gln arg asn leu ser pro ala leu gly gln met pro  2140

   ATT TCT CCA GAC CTC AGC CAT ACA ACC CTT TCT CCA GAC CTC AGC
   ile ser pro asp leu ser his thr thr leu ser pro asp leu ser  2155

   CAT ACA ACC CTT TCT TTA GAC CTC AGC CAG ACA AAC CTC TCT CCA
   his thr thr leu ser leu asp leu ser gln thr asn leu ser pro  2170

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