Рис. MPS III B seq.
Нуклеотидная и аминокислотная последовательности гена
ацетил-а-D-глюкозаминидазы (alpha-N-acetylglucosaminidase)
(NAGLU) человека
ATG GAG GCG GTG GCG GTG GCC GCG GCG GTG GGG GTC CTT CTC CTG
met glu ala val ala val ala ala ala val gly val leu leu leu 15
GCC GGG GCC GGG GGC GCG GCA GGC GAC GAG GCC CGG GAG GCG GCG
ala gly ala gly gly ala ala gly asp glu ala arg glu ala ala 30
GCC GTG CGG GCG CTC GTG GCC CGG CTG CTG GGG CCA GGC CCC GCG
ala val arg ala leu val ala arg leu leu gly pro gly pro ala 45
GCC GAC TTC TCC GTG TCG GTG GAG CGC GCT CTG GCT GCC AAG CCG
ala asp phe ser val ser val glu arg ala leu ala ala lys pro 60
GGC TTG GAC ACC TAC AGC CTG GGC GGC GGC GGC GCG GCG CGC GTG
gly leu asp thr tyr ser leu gly gly gly gly ala ala arg val 75
CGG GTG CGC GGC TCC ACG GGC GTG GCG GCC GCC GCG GGG CTG CAC
arg val arg gly ser thr gly val ala ala ala ala gly leu his 90
CGC TAC CTG CGC GAC TTC TGT GGC TGC CAC GTG GCC TGG TCC GGC
arg tyr leu arg asp phe cys gly cys his val ala trp ser gly 105
TCT CAG CTG CGC CTG CCG CGG CCA CTG CCA GCC GTG CCG GGG GAG
ser gln leu arg leu pro arg pro leu pro ala val pro gly glu 120
CTG ACC GAG GCC ACG CCC AAC AGG TAC CGC TAT TAC CAG AAT GTG
leu thr glu ala thr pro asn arg tyr arg tyr tyr gln asn val 135
TGC ACG CAA AGC TAC TCC TTC GTG TGG TGG GAC TGG GCC CGC TGG
cys thr gln ser tyr ser phe val trp trp asp trp ala arg trp 150
GAG CGA GAG ATA GAC TGG ATG GCG CTG AAT GGC ATC AAC CTG GCA
glu arg glu ile asp trp met ala leu asn gly ile asn leu ala 165
CTG GCC TGG AGC GGC CAG GAG GCC ATC TGG CAG CGG GTG TAC CTG
leu ala trp ser gly gln glu ala ile trp gln arg val tyr leu 180
GCC TTG GGC CTG ACC CAG GCA GAG ATC AAT GAG TTC TTT ACT GGT
ala leu gly leu thr gln ala glu ile asn glu phe phe thr gly 195
CCT GCC TTC CTG GCC TGG GGG CGA ATG GGC AAC CTG CAC ACC TGG
pro ala phe leu ala trp gly arg met gly asn leu his thr trp 210
GAT GGC CCC CTG CCC CCC TCC TGG CAC ATC AAG CAG CTT TAC CTG
asp gly pro leu pro pro ser trp his ile lys gln leu tyr leu 225
CAG CAC CGG GTC CTG GAC CAG ATG CGC TCC TTC GGC ATG ACC CCA
gln his arg val leu asp gln met arg ser phe gly met thr pro 240
GTG CTG CCT GCA TTC GCG GGG CAT GTT CCC GAG GCT GTC ACC AGG
val leu pro ala phe ala gly his val pro glu ala val thr arg 255
GTG TTC CCT CAG GTC AAT GTC ACG AAG ATG GGC AGT TGG GGC CAC
val phe pro gln val asn val thr lys met gly ser trp gly his 270
TTT AAC TGT TCC TAC TCC TGC TCC TTC CTT CTG GCT CCG GAA GAC
phe asn cys ser tyr ser cys ser phe leu leu ala pro glu asp 285
CCC ATA TTC CCC ATC ATC GGG AGC CTC TTC CTG CGA GAG CTG ATC
pro ile phe pro ile ile gly ser leu phe leu arg glu leu ile 300
AAA GAG TTT GGC ACA GAC CAC ATC TAT GGG GCC GAC ACT TTC AAT
lys glu phe gly thr asp his ile tyr gly ala asp thr phe asn 315
GAG ATG CAG CCA CCT TCC TCA GAG CCC TCC TAC CTT GCC GCA GCC
glu met gln pro pro ser ser glu pro ser tyr leu ala ala ala 330
ACC ACT GCC GTC TAT GAG GCC ATG ACT GCA GTG GAT ACT GAG GCT
thr thr ala val tyr glu ala met thr ala val asp thr glu ala 345
GTG TGG CTG CTC CAA GGC TGG CTC TTC CAG CAC CAG CCG CAG TTC
val trp leu leu gln gly trp leu phe gln his gln pro glu phe 360
TGG GGG CCC GCC CAG ATC AGG GCT GTG CTG GGA GCT GTG CCC CGT
trp gly pro ala gln ile arg ala val leu gly ala val pro arg 375
GGC CGC CTC CTG GTT CTG GAC CTG TTT GCT GAG AGC CAG CCT GTG
gly arg leu leu val leu asp leu phe ala glu ser gln pro val 390
TAT ACC CGC ACT GCC TCC TTC CAG GGC CAG CCC TTC ATC TGG TGC
tyr thr arg thr ala ser phe gln gly gln pro phe ile trp cys 405
ATG CTG CAC AAC TTT GGG GGA AAC CAT GGT CTT TTT GGA GCC CTA
met leu his asn phe gly gly asn his gly leu phe gly ala leu 420
GAG GCT GTG AAC GGA GGC CCA GAA GCT GCC CGC CTC TTC CCC AAC
glu ala val asn gly gly pro glu ala ala arg leu phe pro asn 435
TCC ACC ATG GTA GGC ACG GGC ATG GCC CCC GAG GGC ATC AGC CAG
ser thr met val gly thr gly met ala pro glu gly ile ser gln 450
AAC GAA GTG GTC TAT TCC CTC ATG GCT GAG CTG GGC TGG CGA AAG
asn glu val val tyr ser leu met ala glu leu gly trp arg lys 465
GAC CCA GTG CCA GAT TTG GCA GCC TGG GTG ACC AGC TTT GCC GCC
asp pro val pro asp leu ala ala trp val thr ser phe ala ala 480
CGG CGG TAT GGG GTC TCC CAC CCG GAC GCA GGG GCA GCG TGG AGG
arg arg tyr gly val ser his pro asp ala gly ala ala trp arg 495
CTA CTG CTC CGG AGT GTG TAC AAC TGC TCC GGG GAG GCC TGC AGG
leu leu leu arg ser val tyr asn cys ser gly glu ala cys arg 510
GGC CAC AAT CGT AGC CCG CTG GTC AGG CGG CCG TCC CTA CAG ATG
gly his asn arg ser pro leu val arg arg pro ser leu gln met 525
AAT ACC AGC ATC TGG TAC AAC CGA TCT GAT GTG TTT GAG GCC TGG
asn thr ser ile trp tyr asn arg ser asp val phe glu ala trp 540
CGG CTG CTG CTC ACA TCT GCT CCC TCC CTG GCC ACC AGC CCC GCC
arg leu leu leu thr ser ala pro ser leu ala thr ser pro ala 555
TTC CGC TAC GAC CTG CTG GAC CTC ACT CGG CAG GCA GTG CAG GAG
phe arg tyr asp leu leu asp leu thr arg gln ala val gln glu 570
CTG GTC AGC TTG TAC TAT GAG GAG GCA AGA AGC GCC TAC CTG AGC
leu val ser trp tyr tyr glu glu ala arg ser ala tyr leu ser 585
AAG GAG CTG GCC TCC CTG TTG AGG GCT GGA GGC GTC CTG GCC TAT
lys glu leu ala ser leu trp arg ala gly gly val leu ala tyr 600
GAG CTG CTG CCG GCA CTG GAC GAG GTG CTG GCT AGT GAC AGC CGC
glu leu leu pro ala leu asp glu val leu ala ser asp ser arg 615
TTC TTG CTG GGC AGC TGG CTA GAG CAG GCC CGA GCA GCG GCA GTC
phe trp leu gly ser trp leu glu gln ala arg ala ala ala val 630
AGT GAG GCC GAG GCC GAT TTC TAC GAG CAG AAC AGC CGC TAC CAG
ser glu ala glu ala asp phe tyr glu gln asn ser arg tyr gln 645
CTG ACC TTG TGG GGG CCA GAA GGC AAC ATC CTG GAC TAT GCC AAC
leu thr leu trp gly pro glu gly asn ile leu asp tyr ala asn 660
AAG CAG CTG GCG GGG TTG GTG GCC AAC TAC TAC ACC CCT CGC TGG
lys gln leu ala gly leu val ala asn tyr tyr thr pro arg trp 675
CGG CTT TTC CTG GAG GCG CTG GTT GAC AGT GTG GCC CAG GGC ATC
arg leu phe leu glu ala leu val asp ser val ala gln gly ile 690
CCT TTC CAA CAG CAC CAG TTT GAC AAA AAT GTC TTC CAA CTG GAG
pro phe gln gln his gln phe asp lys asn val phe gln leu glu 705
CAG GCC TTC GTT CTC AGC AAG CAG AGG TAC CCC AGC CAG CCG CGA
gln ala phe val leu ser lys gln arg tyr pro ser gln pro arg 720
GGA GAC ACT GTG GAC CTG GCC AAG AAG ATC TTC CTC AAA TAT TAC
gly asp thr val asp leu ala lys lys ile phe leu lys tyr tyr 735
CCC GGC TGG GTG GCC GGC TCT TGG TGA
pro gly trp val ala gly ser trp ter
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