Рис. MPS VII seq (ген GUSB)
Нуклеотидная и аминокислотная последовательности
гена бета-D-глюкуронидазы (glucuronidase beta)
(GUS) человека
ATG GCC CGG GGG TCG GCG GTT GCC TGG GCG GCG CTC GGG CCG TTG
met ala arg gly ser ala val ala trp ala ala leu gly pro leu 15
TTG TGG GGC TGC GCG CTG GGG CTG CAG GGC GGG ATG CTG TAC CCC
leu trp gly cys ala leu gly leu gln gly gly met leu tyr pro 30
CAG GAG AGC CCG TCG CGG GAG TGC AAG GAG CTG GAC GGC CTC TGG
gln glu ser pro ser arg glu cys lys glu leu asp gly leu trp 45
AGC TTC CGC GCC GAC TTC TCT GAC AAC CGA CGC CGG GGC TTC GAG
ser phe arg ala asp phe ser asp asn arg arg arg gly phe glu 60
GAG CAG TGG TAC CGG CGG CCG CTG TGG GAG TCA GGC CCC ACC GTG
glu gln trp tyr arg arg pro leu trp glu ser gly pro thr val 75
GAC ATG CCA GTT CCC TCC AGC TTC AAT GAC ATC AGC CAG GAC TGG
asp met pro val pro ser ser phe asn asp ile ser gln asp trp 90
CGT CTG CGG CAT TTT GTC GGC TGG GTG TGG TAC GAA CGG GAG GTG
arg leu arg his phe val gly trp val trp tyr glu arg glu val 105
ATC CTG CCG GAG CGA TGG ACC CAG GAC CTG CGC ACA AGA GTG GTG
ile leu pro glu arg trp thr gln asp leu arg thr arg val val 120
CTG AGG ATT GGC AGT GCC CAT TCC TAT GCC ATC GTG TGG GTG AAT
leu arg ile gly ser ala his ser tyr ala ile val trp val asn 135
GGG GTC GAC ACG CTA GAG CAT GAG GGG GGC TAC CTC CCC TTC GAG
gly val asp thr leu glu his glu gly gly tyr leu pro phe glu 150
GCC GAC ATC AGC AAC CTG GTC CAG GTG GGG CCC CTG CCC TCC CGG
ala asp ile ser asn leu val gln val gly pro leu pro ser arg 165
CTC CGA ATC ACT ATC GCC ATC AAC AAC ACA CTC ACC CCC ACC ACC
leu arg ile thr ile ala ile asn asn thr leu thr pro thr thr 180
CTG CCA CCA GGG ACC ATC CAA TAC CTG ACT GAC ACC TCC AAG TAT
leu pro pro gly thr ile gln tyr leu thr asp thr ser lys tyr 195
CCC AAG GGT TAC TTT GTC CAG AAC ACA TAT TTT GAC TTT TTC AAC
pro lys gly tyr phe val gln asn thr tyr phe asp phe phe asn 210
TAC GCT GGA CTG CAG CGG TCT GTA CTT CTG TAC ACG ACA CCC ACC
tyr ala gly leu gln arg ser val leu leu tyr thr thr pro thr 225
ACC TAC ATC GAT GAC ATC ACC GTC ACC ACC AGC GTG GAG CAA GAC
thr tyr ile asp asp ile thr val thr thr ser val glu gln asp 240
AGT GGG CTG GTG AAT TAC CAG ATC TCT GTC AAG GGC AGT AAC CTG
ser gly leu val asn tyr gln ile ser val lys gly ser asn leu 255
TTC AAG TTG GAA GTG CGT CTT TTG GAT GCA GAA AAC AAA GTC GTG
phe lys leu glu val arg leu leu asp ala glu asn lys val val 270
GCG AAT GGG ACT GGG ACC CAG GGC CAA CTT AAG GTG CCA GGT GTC
ala asn gly thr gly thr gln gly gln leu lys val pro gly val 285
AGC CTC TGG TGG CCG TAC CTG ATG CAC GAA CGC CCT GCC TAT CTG
ser leu trp trp pro tyr leu met his glu arg pro ala tyr leu 300
TAT TCA TTG GAG GTG CAG CTG ACT GCA CAG ACG TCA CTG GGG CCT
tyr ser leu glu val gln leu thr ala gln thr ser leu gly pro 315
GTG TCT GAC TTC TAC ACA CTC CCT GTG GGG ATC CGC ACT GTG GCT
val ser asp phe tyr thr leu pro val gly ile arg thr val ala 330
GTC ACC AAG AGC CAG TTC CTC ATC AAT GGG AAA CCT TTC TAT TTC
val thr lys ser gln phe leu ile asn gly lys pro phe tyr phe 345
CAC GGT GTC AAC AAG CAT GAG GAT GCG GAC ATC CGA GGG AAG GGC
his gly val asn lys his glu asp ala asp ile arg gly lys gly 360
TTC GAC TGG CCG CTG CTG GTG AAG GAC TTC AAC CTG CTT CGC TGG
phe asp trp pro leu leu val lys asp phe asn leu leu arg trp 375
CTT GGT GCC AAC GCT TTC CGT ACC AGC CAC TAC CCC TAT GCA GAG
leu gly ala asn ala phe arg thr ser his tyr pro tyr ala glu 390
GAA GTG ATG CAG ATG TGT GAC CGC TAT GGG ATT GTG GTC ATC GAT
glu val met gln met cys asp arg tyr gly ile val val ile asp 405
GAG TGT CCC GGC GTG GGC CTG GCG CTG CCG CAG TTC TTC AAC AAC
glu cys pro gly val gly leu ala leu pro gln phe phe asn asn 420
GTT TCT CTG CAT CAC CAC ATG CAG GTG ATG GAA GAA GTG GTG CGT
val ser leu his his his met gln val met glu glu val val arg 435
AGG GAC AAG AAC CAC CCC GCG GTC GTG ATG TGG TCT GTG GCC AAC
arg asp lys asn his pro ala val val met trp ser val ala asn 450
GAG CCT GCG TCC CAC CTA GAA TCT GCT GGC TAC TAC TTG AAG ATG
glu pro ala ser his leu glu ser ala gly tyr tyr leu lys met 465
GTG ATC GCT CAC ACC AAA TCC TTG GAC CCC TCC CGG CCT GTG ACC
val ile ala his thr lys ser leu asp pro ser arg pro val thr 480
TTT GTG AGC AAC TCT AAC TAT GCA GCA GAC AAG GGG GCT CCG TAT
phe val ser asn ser asn tyr ala ala asp lys gly ala pro tyr 495
GTG GAT GTG ATC TGT TTG AAC AGC TAC TAC TCT TGG TAT CAC GAC
val asp val ile cys leu asn ser tyr tyr ser trp tyr his asp 510
TAC GGG CAC CTG GAG TTG ATT CAG CTG CAG CTG GCC ACC CAG TTT
tyr gly his leu glu leu ile gln leu gln leu ala thr gln phe 525
GAG AAC TGG TAT AAG AAG TAT CAG AAG CCC ATT ATT CAG AGC GAG
glu asn trp tyr lys lys tyr gln lys pro ile ile gln ser glu 540
TAT GGA GCA GAA ACG ATT GCA GGG TTT CAC CAG GAT CCA CCT CTG
tyr gly ala glu thr ile ala gly phe his gln asp pro pro leu 555
ATG TTC ACT GAA GAG TAC CAG AAA AGT CTG CTA GAG CAG TAC CAT
met phe thr glu glu tyr gln lys ser leu leu glu gln tyr his 570
CTG GGT CTG GAT CAA AAA CGC AGA AAA TAT GTG GTT GGA GAG CTC
leu gly leu asp gln lys arg arg lys tyr val val gly glu leu 585
ATT TGG AAT TTT GCC GAT TTC ATG ACT GAA CAG TCA CCG ACG AGA
ile trp asn phe ala asp phe met thr glu gln ser pro thr arg 600
GTG CTG GGG AAT AAA AAG GGG ATC TTC ACT CGG CAG AGA CAA CCA
val leu gly asn lys lys gly ile phe thr arg gln arg gln pro 615
AAA AGT GCA GCG TTC CTT TTG CGA GAG AGA TAC TGG AAG ATT GCC
lys ser ala ala phe leu leu arg glu arg tyr trp lys ile ala 630
AAT GAA ACC AGG TAT CCC CAC TCA GTA GCC AAG TCA CAA TGT TTG
asn glu thr arg tyr pro his ser val ala lys ser gln cys leu 645
GAA AAC AGC CCG TTT ACT TGA
glu asn ser pro phe thr ter
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