Рис. Col I AII seq
Нуклеотидная и аминокислотная последовательности
гена коллагена I типа альфа II (col I AII) человека
ATG CTC AGC TTT GTG GAT ACG CGG ACT TTG TTG CTG CTT GCA GTA
met leu ser phe val asp thr arg thr leu leu leu leu ala val 15
ACC TTA TGC CTA GCA ACA TGC CAA TCT TTA CAA GAG GAA ACT GTA
thr leu cys leu ala thr cys gln ser leu gln glu glu thr val 30
AGA AAG GGC CCA GCC GGA GAT AGA GGA CCA CGT GGA GAA AGG GGT
arg lys gly pro ala gly asp arg gly pro arg gly glu arg gly 45
CCA CCA GGC CCC CCA GGC AGA GAT GGT GAA GAT GGT CCC ACA GGC
pro pro gly pro pro gly arg asp gly glu asp gly pro thr gly 60
CCT CCT GGT CCA CCT GGT CCT CCT GGC CCC CCT GGT CTC GGT GGG
pro pro gly pro pro gly pro pro gly pro pro gly leu gly gly 75
AAC TTT GCT GCT CAG TAT GAT GGA AAA GGA GTT GGA CTT GGC CCT
asn phe ala ala gln tyr asp gly lys gly val gly leu gly pro 90
GGA CCA ATG GGC TTA ATG GGA CCT AGA GGC CCA CCT GGT GCA GCT
gly pro met gly leu met gly pro arg gly pro pro gly ala ala 105
GGA GCC CCA GGC CCT CAA GGT TTC CAA GGA CCT GCT GGT GAG CCT
gly ala pro gly pro gln gly phe gln gly pro ala gly glu pro 120
GGT GAA CCT GGT CAA ACT GGT CCT GCA GGT GCT CGT GGT CCA GCT
gly glu pro gly gln thr gly pro ala gly ala arg gly pro ala 135
GGC CCT CCT GGC AAG GCT GGT GAA GAT GGT CAC CCT GGA AAA CCC
gly pro pro gly lys ala gly glu asp gly his pro gly lys pro 150
GGA CGA CCT GGT GAG AGA GGA GTT GTT GGA CCA CAG GGT GCT CGT
gly arg pro gly glu arg gly val val gly pro gln gly ala arg 165
GGT TTC CCT GGA ACT CCT GGA CTT CCT GGC TTC AAA GGC ATT AGG
gly phe pro gly thr pro gly leu pro gly phe lys gly ile arg 180
GGA CAC AAT GGT CTG GAT GGA TTG AAG GGA CAG CCC GGT GCT CCT
gly his asn gly leu asp gly leu lys gly gln pro gly ala pro 195
GGT GTG AAG GGT GAA CCT GGT GCC CCT GGT GAA AAT GGA ACT CCA
gly val lys gly glu pro gly ala pro gly glu asn gly thr pro 210
GGT CAA ACA GGA GCC CGT GGG CTT CCT GGT GAG AGA GGA CGT GTT
gly gln thr gly ala arg gly leu pro gly glu arg gly arg val 225
GGT GCC CCT GGC CCA GCT GGT GCC CGT GGC AGT GAT GGA AGT GTG
gly ala pro gly pro ala gly ala arg gly ser asp gly ser val 240
GGT CCC GTG GGT CCT GCT GGT CCC ATT GGG TCT GCT GGC CCT CCA
gly pro val gly pro ala gly pro ile gly ser ala gly pro pro 255
GGC TTC CCA GGT GCC CCT GGC CCC AAG GGT GAA ATT GGA GCT GTT
gly phe pro gly ala pro gly pro lys gly glu ile gly ala val 270
GGT AAC GCT GGT CCT GCT GGT CCC GCC GGT CCC CGT GGT GAA GTG
gly asn ala gly pro ala gly pro ala gly pro arg gly glu val 285
GGT CTT CCA GGC CTC TCC GGC CCC GTT GGA CCT CCT GGT AAT CCT
gly leu pro gly leu ser gly pro val gly pro pro gly asn pro 300
GGA GCA AAC GGC CTT ACT GGT GCC AAG GGT GCT GCT GGC CTT CCC
gly ala asn gly leu thr gly ala lys gly ala ala gly leu pro 315
GGC GTT GCT GGG GCT CCC GGC CTC CCT GGA CCC CGC GGT ATT CCT
gly val ala gly ala pro gly leu pro gly pro arg gly ile pro 330
GGC CCT GTT GGT GCT GCC GGT GCT ACT GGT GCC AGA GGA CTT GTT
gly pro val gly ala ala gly ala thr gly ala arg gly leu val 345
GGT GAG CCT GGT CCA GCT GGC TCC AAA GGA GAG AGC GGT AAC AAG
gly glu pro gly pro ala gly ser lys gly glu ser gly asn lys 360
GGT GAG CCC GGC TCT GCT GGG CCC CAA GGT CCT CCT GGT CCC AGT
gly glu pro gly ser ala gly pro gln gly pro pro gly pro ser 375
GGT GAA GAA GGA AAG AGA GGC CCT AAT GGG GAA GCT GGA TCT GCC
gly glu glu gly lys arg gly pro asn gly glu ala gly ser ala 390
GGC CCT CCA GGA CCT CCT GGG CTG AGA GGT AGT CCT GGT TCT CGT
gly pro pro gly pro pro gly leu arg gly ser pro gly ser arg 405
GGT CTT CCT GGA GCT GAT GGC AGA GCT GGC GTC ATG GGC CCT CCT
gly leu pro gly ala asp gly arg ala gly val met gly pro pro 420
GGT AGT CGT GGT GCA AGT GGC CCT GCT GGA GTC CGA GGA CCT AAT
gly ser arg gly ala ser gly pro ala gly val arg gly pro asn 435
GGA GAT GCT GGT CGC CCT GGG GAG CCT GGT CTC ATG GGA CCC AGA
gly asp ala gly arg pro gly glu pro gly leu met gly pro arg 450
GGT CTT CCT GGT TCC CCT GGA AAT ATC GGC CCC GCT GGA AAA GAA
gly leu pro gly ser pro gly asn ile gly pro ala gly lys glu 465
GGT CCT GTC GGC CTC CCT GGC ATC GAC GGC AGG CCT GGC CCA ATT
gly pro val gly leu pro glu ile asp gly arg pro gly pro ile 480
GGC CCA GCT GGA GCA AGA GGA GAG CCT GGC AAC ATT GGA TTC CCT
gly pro ala gly ala arg gly glu pro gly asn ile gly phe pro 495
GGA CCC AAA GGC CCC ACT GGT GAT CCT GGC AAA AAC GGT GAT AAA
gly pro lys gly pro thr gly asp pro gly lys asn gly asp lys 510
GGT CAT GCT GGT CTT GCT GGT GCT CGG GGT GCT CCA GGT CCT GAT
gly his ala gly leu ala gly ala arg gly ala pro gly pro asp 525
GGA AAC AAT GGT GCT CAG GGA CCT CCT GGA CCA CAG GGT GTT CAA
gly asn asn gly ala gln gly pro pro gly pro gln gly val gln 540
GGT GGA AAA GGT GAA CAG GGT CCC GCT GGT CCT CCA GGC TTC CAG
gly gly lys gly glu gln gly pro ala gly pro pro gly phe gln 555
GGT CTG CCT GGC CCC TCA GGT CCC GCT GGT GAA GTT GGC AAA CCA
gly leu pro gly pro ser gly pro ala gly glu val gly lys pro 570
GGA GAA AGG GGT CTC CAT GGT GAG TTT GGT CTC CCT GGT CCT GCT
gly glu arg gly leu his gly glu phe gly leu pro gly pro ala 585
GGT CCA AGA GGG GAA CGC GGT CCC CCA GGT GAG AGT GGT GCT GCC
gly pro arg gly glu arg gly pro pro gly glu ser gly ala ala 600
GGT CCT ACT GGT CCT ATT GGA AGC CGA GGT CCT TCT GGA CCC CCA
gly pro thr gly pro ile gly ser arg gly pro ser gly pro pro 615
GGG CCT GAT GGA AAC AAG GGT GAA CCT GGT GTG GTT GGT GCT GTG
gly pro asp gly asn lys gly glu pro gly val val gly ala val 630
GGC ACT GCT GGT CCA TCT GGT CCT AGT GGA CTC CCA GGA GAG AGG
gly thr ala gly pro ser gly pro ser gly leu pro gly glu arg 645
GGT GCT GCT GGC ATA CCT GGA GGC AAG GGA GAA AAG GGT GAA CCT
gly ala ala gly ile pro gly gly lys gly glu lys gly glu pro 660
GGT CTC AGA GGT GAA ATT GGT AAC CCT GGC AGA GAT GGT GCT CGT
gly leu arg gly glu ile gly asn pro gly arg asp gly ala arg 675
GGT GCT CAT GGT GCT GTA GGT GCC CCT GGT CCT GCT GGA GCC ACA
gly ala his gly ala val gly ala pro gly pro ala gly ala thr 690
GGT GAC CGG GGC GAA GCT GGG GCT GCT GGT CCT GCT GGT CCT GCT
gly asp arg gly glu ala gly ala ala gly pro ala gly pro ala 705
GGT CCT CGG GGA AGC CCT GGT GAA CGT GGC GAG GTC GGT CCT GCT
gly pro arg gly ser pro gly glu arg gly glu val gly pro ala 720
GGC CCC AAC GGA TTT GCT GGT CCG GCT GGT GCT GCT GGT CAA CCG
gly pro asn gly phe ala gly pro ala gly ala ala gly gln pro 735
GGT GCT AAA GGA GAA AGA GGA GCC AAA GGG CCT AAG GGT GAA AAC
gly ala lys gly glu arg gly ala lys gly pro lys gly glu asn 750
GGT GTT GTT GGT CCC ACA GGC CCC GTT GGA GCT GCT GGC CCA GCT
gly val val gly pro thr gly pro val gly ala ala gly pro ala 765
GGT CCA AAT GGT CCC CCC GGT CCT GCT GGA AGT CGT GGT GAT GGA
gly pro asn gly pro pro gly pro ala gly ser arg gly asp gly 780
GGC CCC CCT GGT ATG ACT GGT TTC CCT GGT GCT GCT GGA CGG ACT
gly pro pro gly met thr gly phe pro gly ala ala gly arg thr 795
GGT CCC CCA GGA CCC TCT GGT ATT TCT GGC CCT CCT GGT CCC CCT
gly pro pro gly pro ser gly ile ser gly pro pro gly pro pro 810
GGT CCT GCT GGG AAA GAA GGG CTT CGT GGT CCT CGT GGT GAC CAA
gly pro ala gly lys glu gly leu arg gly pro arg gly asp gln 825
GGT CCA GTT GGC CGA ACT GGA GAA GTA GGT GCA GTT GGT CCC CCT
gly pro val gly arg thr gly glu val gly ala val gly pro pro 840
GGC TTC GCT GGT GAG AAG GGT CCC TCT GGA GAG GCT GGT ACT GCT
gly phe ala gly glu lys gly pro ser gly glu ala gly thr ala 855
GGA CCT CCT GGC ACT CCA GGT CCT CAG GGT CTT CTT GGT GCT CCT
gly pro pro gly thr pro gly pro gln gly leu leu gly ala pro 870
GGT ATT CTG GGT CTC CCT GGC TCG AGA GGT GAA CGT GGT CTA CCT
gly ile leu gly leu pro gly ser arg gly glu arg gly leu pro 885
GGT GTT GCT GGT GCT GTG GGT GAA CCT GGT CCT CTT GGC ATT GCC
gly val ala gly ala val gly glu pro gly pro leu gly ile ala 900
GGC CCT CCT GGG GCC CGT GGT CCT CCT GGT GCT GTG GGT AGT CCT
gly pro pro gly ala arg gly pro pro gly ala val gly ser pro 915
GGA GTC AAC GGT GCT CCT GGT GAA GCT GGT CGT GAT GGC AAC CCT
gly val asn gly ala pro gly glu ala gly arg asp gly asn pro 930
GGG AAC GAT GGT CCC CCA GGT CGC GAT GGT CAA CCC GGA CAC AAG
gly asn asp gly pro pro gly arg asp gly gln pro gly his lys 945
GGA GAG CGC GGT TAC CCT GGC AAT ATT GGT CCC GTT GGT GCT GCA
gly glu arg gly tyr pro gly asn ile gly pro val gly ala ala 960
GGT GCA CCT GGT CCT CAT GGC CCC GTG GGT CCT GCT GGC AAA CAT
gly ala pro gly pro his gly pro val gly pro ala gly lys his 975
GGA AAC CGT GGT GAA ACT GGT CCT TCT GGT CCT GTT GGT CCT GCT
gly asn arg gly glu thr gly pro ser gly pro val gly pro ala 990
GGT GCT GTT GGC CCA AGA GGT CCT AGT GGC CCA CAA GGC ATT CGT
gly ala val gly pro arg gly pro ser gly pro gln gly ile arg 1005
GGC GAT AAG GGA GAG CCC GGT GAA AAG GGG CCC AGA GGT CTT CCT
gly asp lys gly glu pro gly glu lys gly pro arg gly leu pro 1020
GGC TTA AAG GGA CAC AAT GGA TTG CAA GGT CTG CCT GGT ATC GCT
gly leu lys gly his asn gly leu gln gly leu pro gly ile ala 1035
GGT CAC CAT GGT GAT CAA GGT GCT CCT GGC TCC GTG GGT CCT GCT
gly his his gly asp gln gly ala pro gly ser val gly pro ala 1050
GGT CCT AGG GGC CCT GCT GGT CCT TCT GGC CCT GCT GGA AAA GAT
gly pro arg gly pro ala gly pro ser gly pro ala gly lys asp 1065
GGT CGC ACT GGA CAT CCT GGT ACG GTT GGA CCT GCT GGC ATT CGA
gly arg thr gly his pro gly thr val gly pro ala gly ile arg 1080
GGC CCT CAG GGT CAC CAA GGC CCT GCT GGC CCC CCT GGT CCC CCT
gly pro gln gly his gln gly pro ala gly pro pro gly pro pro 1095
GGC CCT CCT GGA CCT CCA GGT GTA AGC GGT GGT GGT TAT GAC TTT
gly pro pro gly pro pro gly val ser gly gly tyr tyr asp phe 1110
GGT TAC GAT GGA GAC TTC TAC AGG GCT GAC CAG CCT CGC TCA GCA
gly tyr asp gly asp phe tyr arg ala asp gln pro arg ser ala 1125
CCT TCT CTC AGA CCC AAG GAC TAT GAA GTT GAT GCT ACT CTG AAG
pro ser leu arg pro lys asp tyr glu val asp ala thr leu lys 1140
TCT CTC AAC AAC CAG ATT GAG ACC CTT CTT ACT CCT GAA GGC TCT
ser leu asn asn gln ile glu thr leu leu thr pro glu gly ser 1155
AGA AAG AAC CCA GCT CGC ACA TGC CGT GAC TTG AGA CTC AGC CAC
arg lys asn pro ala arg thr cys arg asp leu arg leu ser his 1170
CCA GAG TGG AGC AGT GGT TAC TAC TGG ATT GAC CCT AAC CAA GGA
pro glu trp ser ser gly tyr tyr trp ile asp pro asn gln gly 1185
TGC ACT ATG GAT GCT ATC AAA GTA TAC TGT GAT TTC TCT ACT GGC
cys thr met asp ala ile lys val tyr cys asp phe ser thr gly 1200
GAA ACC TGT ATC CGG GCC CAA CCT GAA AAC ATC CCA GCC AAG AAC
glu thr cys ile arg ala gln pro glu asn ile pro ala lys asn 1215
TGG TAT AGG AGC TCC AAG GAC AAG AAA CAC GTC TGG CTA GGA GAA
trp tyr arg ser ser lys asp lys lys his val trp leu gly glu 1230
ACT ATC AAT GCT GGC AGC CAG TTT GAA TAT AAT GTA GAA GGA GTG
thr ile asn ala gly arg gln phe glu tyr asn val glu gly val 1245
ACT TCC AAG GAA ATG GCT ACC CAA CTT GCC TTC ATG CGC CTG CTG
thr ser lys glu met ala thr gln leu ala phe met arg leu leu 1260
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