Рис. Col VII AI seq
Нуклеотидная и аминокислотная последовательности
гена коллагена VII типа альфа I (COL VII AI) человека
ATG ACG CTG CGG CTT CTG GTG GCC GCG CTC TGC GCC GGG ATC CTG
met thr leu arg leu leu val ala ala leu cys ala gly ile leu 15
GCA GAG GCG CCC CGA GTG CGA GCC CAG CAC AGG GAG AGA GTG ACC
ala glu ala pro arg val arg ala gln his arg glu arg val thr 30
TGC ACG CGC CTT TAC GCC GCT GAC ATT GTG TTC TTA CTG GAT GGC
cys thr arg leu tyr ala ala asp ile val phe leu leu asp gly 45
TCC TCA TCC ATT GGC CGC AGC AAT TTC CGC GAG GTC CGC AGC TTT
ser ser ser ile gly arg ser asn phe arg glu val arg ser phe 60
CTC GAA GGG CTG GTG CTG CCT TTC TCT GGA GCA GCC AGT GCA CAG
leu glu gly leu val leu pro phe ser gly ala ala ser ala gln 75
GGT GTG CGC TTT GCC ACA GTG CAG TAC AGC GAT GAC CCA CGG ACA
gly val arg phe ala thr val gln tyr ser asp asp pro arg thr 90
GAG TTC GGC CTG GAT GCA CTT GGC TCT GGG GGT GAT GTG ATC CGC
glu phe gly leu asp ala leu gly ser gly gly asp val ile arg 105
GCC ATC CGT GAG CTT AGC TAC AAG GGG GGC AAC ACT CGC ACA GGG
ala ile arg glu leu ser tyr lys gly gly asn thr arg thr gly 120
GCT GCA ATT CTC CAT GTG GCT GAC CAT GTC TTC CTG CCC CAG CTG
ala ala ile leu his val ala asp his val phe leu pro gln leu 135
GCC CGA CCT GGT GTC CCC AAG GTC TGC ATC CTG ATC ACA GAC GGG
ala arg pro gly val pro lys val cys ile leu ile thr asp gly 150
AAG TCC CAG GAC CTG GTG GAC ACA GCT GCC CAA AGG CTG AAG GGG
lys ser gln asp leu val asp thr ala ala gln arg leu lys gly 165
CAG GGG GTC AAG CTA TTT GCT GTG GGG ATC AAG AAT GCT GAC CCT
gln gly val lys leu phe ala val gly ile lys asn ala asp pro 180
GAG GAG CTG AAG CGA GTT GCC TCA CAG CCA ACC TCC GAC TTC TTC
glu glu leu lys arg val ala ser gln pro thr ser asp phe phe 195
TTC TTC GTC AAT GAC TTC AGC ATC TTG AGG ACA CTA CTG CCC CTC
phe phe val asn asp phe ser ile leu arg thr leu leu pro leu 210
GTT TCC CGG AGA GTG TGC ACG ACT GCT GGT GGC GTG CCT GTG ACC
val ser arg arg val cys thr thr ala gly gly val pro val thr 225
CGA CCT CCG GAT GAC TCG ACC TCT GCT CCA CGA GAC CTG GTG CTG
arg pro pro asp asp ser thr ser ala pro arg asp leu val leu 240
TCT GAG CCA AGC AGC CAA TCC TTG AGA GTA CAG TGG ACA GCG GCC
ser glu pro ser ser gln ser leu arg val gln trp thr ala ala 255
AGT GGC CCT GTG ACT GGC TAC AAG GTC CAG TAC ACT CCT CTG ACG
ser gly pro val thr gly tyr lys val gln tyr thr pro leu thr 270
GGG CTG GGA CAG CCA CTG CCG AGT GAG CGG CAG GAG GTG AAC GTC
gly leu gly gln pro leu pro ser glu arg gln glu val asn val 285
CCA GCT GGT GAG ACC AGT GTG CGG CTG CGG GGT CTC CGG CCA CTG
pro ala gly glu thr ser val arg leu arg gly leu arg pro leu 300
ACC GAG TAC CAA GTG ACT GTG ATT GCC CTC TAC GCC AAC AGC ATC
thr glu tyr gln val thr val ile ala leu tyr ala asn ser ile 315
GGG GAG GCT GTG AGC GGG ACA GCT CGG ACC ACT GCC CTA GAA GGG
gly glu ala val ser gly thr ala arg thr thr ala leu glu gly 330
CCG GAA CTG ACC ATC CAG AAT ACC ACA GCC CAC AGC CTC CTG GTG
pro glu leu thr ile gln asn thr thr ala his ser leu leu val 345
GCC TGG CGG AGT GTG CCA GGT GCC ACT GGC TAC CGT GTG ACA TGG
ala trp arg ser val pro gly ala thr gly tyr arg val thr trp 360
CGG GTC CTC AGT GGT GGG CCC ACA CAG CAG CAG GAG CTG GGC CCT
arg val leu ser gly gly pro thr gln gln gln glu leu gly pro 375
GGG CAG GGT TCA GTG TTG CTG CGT GAC TTG GAG CCT GGC ACG GAC
gly gln gly ser val leu leu arg asp leu glu pro gly thr asp 390
TAT GAG GTG ACC GTG AGC ACC CTA TTT GGC CGC AGT GTG GGG CCC
tyr glu val thr val ser thr leu phe gly arg ser val gly pro 405
GCC ACT TCC CTG ATG GCT CGC ACT GAC GCT TCT GTT GAG CAG ACC
ala thr ser leu met ala arg thr asp ala ser val glu gln thr 420
CTG CGC CCG GTC ATC CTG GGC CCC ACA TCC ATC CTC CTT TCC TGG
leu arg pro val ile leu gly pro thr ser ile leu leu ser trp 435
AAC TTG GTG CCT GAG GCC CGT GGC TAC CGG TTG GAA TGG CGG CGT
asn leu val pro glu ala arg gly tyr arg leu glu trp arg arg 450
GAG ACT GGC TTG GAG CCA CCG CAG AAG GTG GTA CTG CCC TCT GAT
glu thr gly leu glu pro pro gln lys val val leu pro ser asp 465
GTG ACC CGC TAC CAG TTG GAT GGG CTG CAG CCG GGC ACT GAG TAC
val thr arg tyr glu leu asp gly leu gln pro gly thr glu tyr 480
CGC CTC ACA CTC TAC ACT CTG CTG GAG GGC CAC GAG GTG GCC ACC
arg leu thr leu tyr thr leu leu glu gly his glu val ala thr 495
CCT GCA ACC GTG GTT CCC ACT GGA CCA GAG CTG CCT GTG AGC CCT
pro ala thr val val pro thr gly pro glu leu pro val ser pro 510
GTA ACA GAC CTG CAA GCC ACC GAG CTG CCC GGG CAG CGG GTG CGA
val thr asp leu gln ala thr glu leu pro gly glu arg val arg 525
GTG TCC TGG AGC CCA GTC CCT GGT GCC ACC CAG TAC CGC ATC ATT
val ser trp ser pro val pro gly ala thr gln tyr arg ile ile 540
GTG CGC AGC ACC CAG GGG GTG GAG CGG ACC CTG GTG CTT CCT GGG
val arg ser thr gln gly val glu arg thr leu val leu pro gly 555
AGT CAG ACA GCA TTC GAC TTG GAT GAC GTT CAG GCT GGG CTT AGC
ser gln thr ala phe asp leu asp asp val gln ala gly leu ser 570
TAC ACT GTG CGG GTG TCT GCT CGA GTG GGT CCC CGT GAG GGC AGT
tyr thr val arg val ser ala arg val gly pro arg glu gly ser 585
GCC AGT GTC CTC ACT GTC CGC CGG GAG CCG GAA ACT CCA CTT GCT
ala ser val leu thr val arg arg glu pro glu thr pro leu ala 600
GTT CCA GGG CTG CGG GTT GTG GTG TCA GAT GCA ACG CGA GTG AGG
val pro gly leu arg val val val ser asp ala thr arg val arg 615
GTG GCC TGG GGA CCC GTC CCT GGA GCC AGT GGA TTT CGG ATT AGC
val ala trp gly pro val pro gly ala ser gly phe arg ile ser 630
TGG AGC ACA GGC AGT GGT CCG GAG TCC AGC CAG ACA CTG CCC CCA
trp ser thr gly ser gly pro glu ser ser gln thr leu pro pro 645
GAC TCT ACT GCC ACA GAC ATC ACA GGG CTG CAG CCT GGA ACC ACC
asp ser thr ala thr asp ile thr gly leu gln pro gly thr thr 660
TAC CAG GTG GCT GTG TCG GTA CTG CGA GGC AGA GAG GAG GGC CCT
tyr gln val ala val ser val leu arg gly arg glu glu glu pro 675
GCT GCA GTC ATC GTG GCT CGA ACG GAC CCA CTG GGC CCA GTG AGG
ala ala val ile val ala arg thr asp pro leu gly pro val arg 690
ACG GTC CAT GTG ACT CAG GCC AGC AGC TCA TCT GTC ACC ATT ACC
thr val his val thr gln ala ser ser ser ser val thr ile thr 705
TGG ACC AGG GTT CCT GGC GCC ACA GGA TAC AGG GTT TCC TGG CAC
trp thr arg val pro gly ala thr gly tyr arg val ser trp his 720
TCA GCC CAC GGC CCA GAG AAA TCC CAG TTG GTT TCT GGG GAG GCC
ser ala his gly pro glu lys ser gln leu val ser gly glu ala 735
ACG GTG GCT GAG CTG GAT GGA CTG GAG CCA GAT ACT GAG TAT ACG
thr val ala glu leu asp gly leu glu pro asp thr glu tyr thr 750
GTG CAT GTG AGG GCC CAT GTG GCT GGC GTG GAT GGG CCC CCT GCC
val his val arg ala his val ala gly val asp gly pro pro ala 765
TCT GTG GTT GTG AGG ACT GCC CCT GAG CCT GTG GGT CGT GTG TCG
ser val val val arg thr ala pro glu pro val gly arg val ser 780
AGG CTG CAG ATC CTC AAT GCT TCC AGC GAC GTT CTA CGG ATC ACC
arg leu gln ile leu asn ala ser ser asp val leu arg ile thr 795
TGG GTA GGG GTC ACT GGA GCC ACA GCT TAC AGA CTG GCC TGG GGC
trp val gly val thr gly ala thr ala tyr arg leu ala trp gly 810
CGG AGT GAA GGC GGC CCC ATG AGG CAC CAG ATA CTC CCA GGA AAC
arg ser glu gly gly pro met arg his gln ile leu pro gly asn 825
ACA GAC TCT GCA GAG ATC CGG GGT CTC GAA GGT GGA GTC AGC TAC
thr asp ser ala glu ile arg gly leu glu gly gly val ser tyr 840
TCA GTG CGA GTG ACT GCA CTT GTC GGG GAC CGC GAG GGC ACA CCT
ser val arg val thr ala leu val gly asp arg glu gly thr pro 855
GTC TCC ATT GTT GTC ACT ACG CCG CCT GAG GCT CCG CCA GCC CTG
val ser ile val val thr thr pro pro glu ala pro pro ala leu 870
GGG ACG CTT CAC GTG GTG CAG CGC GGG GAG CAC TCG CTG AGG CTG
gly thr leu his val val gln arg gly glu his ser leu arg leu 885
CGC TGG GAG CCG GTG CCC AGA GCG CAG GGC TTC CTT CTG CAC TGG
arg trp glu pro val pro arg ala gln gly phe leu leu his trp 900
CAA CCT GAG GGT GGC CAG GAA CAG TCC CGG GTC CTG GGG CCC GAG
gln pro glu gly gly gln glu gln ser arg val leu gly pro glu 915
CTC AGC AGC TAT CAC CTG GAC GGG CTG GAG CCA GCG ACA CAG TAC
leu ser ser tyr his leu asp gly leu glu pro ala thr gln tyr 930
CGC GTG AGG CTG AGT GTC CTA GGG CCG GCT GGA GAA GGG CCC TCT
arg val arg leu ser val leu gly pro ala gly glu gly pro ser 945
GCA GAG GTG ACT GCG CGC ACT GAG TCA CCT CGT GTT CCA AGC ATT
ala glu val thr ala arg thr glu ser pro arg val pro ser ile 960
GAA CTA CGT GTG GTG GAC ACC TCG ATC GAC TCG GTG ACT TTG GCC
glu leu arg val val asp thr ser ile asp ser val thr leu ala 975
TGG ACT CCA GTG TCC AGG GCA TCC AGC TAC ATC CTA TCC TGG CGG
trp thr pro val ser arg ala ser ser tyr ile leu ser trp arg 990
CCA CTC AGA GGC CCT GGC CAG GAA GTG CCT GGG TCC CCG CAG ACA
pro leu arg gly pro gly gln glu val pro gly ser pro gln thr 1005
CTT CCA GGG ATC TCA AGC TCC CAG CGG GTG ACA GGG CTA GAG CCT
leu pro gly ile ser ser ser gln arg val thr gly leu glu pro 1020
GGC GTC TCT TAC ATC TTC TCC CTG ACG CCT GTC CTG GAT GGT GTG
gly val ser tyr ile phe ser leu thr pro val leu asp gly val 1035
CGG GGT CCT GAG GCA TCT GTC ACA CAG ACG CCA GTG TGC CCC CGT
arg gly pro glu ala ser val thr glu thr pro val cys pro arg 1050
GGC CTG GCG GAT GTG GTG TTC CTA CCA CAT GCC ACT CAA GAC AAT
gly leu ala asp val val phe leu pro his ala thr gln asp asn 1065
GCT CAC CGT GCG GAG GCT ACG AGG AGG GTC CTG GAG CGT CTG GTG
ala his arg ala glu ala thr arg arg val leu glu arg leu val 1080
TTG GCA CTT GGG CCT CTT GGG CCA CAG GCA GTT CAG GTT GGC CTG
leu ala leu gly pro leu gly pro gln ala val gln val gly leu 1095
CTG TCT TAC AGT CAT CGG CCT TCC CCA CTG TTC CCA CTG AAT GGC
leu ser tyr ser his arg pro ser pro leu phe pro leu asn gly 1110
TCC CAT GAC CTT GGC ATT ATC TTG CAA AGG ATC CGT GAC ATG CCC
ser his asp leu gly ile ile leu gln arg ile arg asp met pro 1125
TAC ATG GAC CCA AGT GGG AAC AAC CTG GGC ACA GCC GTG GTC ACA
tyr met asp pro ser gly asn asn leu gly thr ala val val thr 1140
GCT CAC AGA TAC ATG TTG GCA CCA GAT GCT CCT GGG CGC CGC CAG
ala his arg tyr met leu ala pro asp ala pro gly arg arg gln 1155
CAC GTA CCA GGG GTG ATG GTT CTG CTA GTG GAT GAA CCC TTG AGA
his val pro gly val met val leu leu val asp glu pro leu arg 1170
GGT GAC ATA TTC AGC CCC ATC CGT GAG GCC CAG GCT TCT GGG CTT
gly asp ile phe ser pro ile arg glu ala gln ala ser gly leu 1185
AAT GTG GTG ATG TTG GGA ATG GCT GGA GCG GAC CCA GAG CAG CTG
asn val val met leu gly met ala gly ala asp pro glu gln leu 1200
CGT CGC TTG GCG CCG GGT ATG GAC TCT GTC CAG ACC TTC TTC GCC
arg arg leu ala pro gly met asp ser val gln thr phe phe ala 1215
GTG GAT GAT GGG CCA AGC CTG GAC CAG GCA GTC AGT GGT CTG GCC
val asp asp gly pro ser leu asp gln ala val ser gly leu ala 1230
ACA GCC CTG TGT CAG GCA TCC TTC ACT ACT CAG CCC CGG CCA GAG
thr ala leu cys gln ala ser phe thr thr gln pro arg pro glu 1245
CCC TGC CCA GTG TAT TGT CCA AAG GGC CAG AAG GGG GAA CCT GGA
pro cys pro val tyr cys pro lys gly gln lys gly glu pro gly 1260
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