Рис. Col I AI seq
Нуклеотидная и аминокислотная последовательности
гена коллагена I типа альфа I (COL I AI) человека
ATG TTC AGC TTT GTG GAC CTC CGG CTC CTG CTC CTC TTA GCG GCC
met phe ser phe val asp leu arg leu leu leu leu leu ala ala 15
ACC GCC CTC CTG ACG CAC GGC CAA GAG GAA GGC CAA GTC GAG GGC
thr ala leu leu thr his gly gln glu glu gly gln val glu gly 30
CAA GAC GAA GAC ATC CCA CCA ATC ACC TGC GTA CAG AAC GGC CTC
gln asp glu asp ile pro pro ile thr cys val gln asn gly leu 45
AGG TAC CAT GAC CGA GAC GTG TGG AAA CCC GAG CCC TGC CGG ATC
arg tyr his asp arg asp val trp lys pro glu pro cys arg ile 60
TGC GTC TGC GAC AAC GGC AAG GTG TTG TGC GAT GAC GTG ATC TGT
cys val cys asp asn gly lys val leu cys asp asp val ile cys 75
GAC GAG ACC AAG AAC TGC CCC GGC GCC GAA GTC CCC GAG GGC GAG
asp glu thr lys asn cys pro gly ala glu val pro glu gly glu 90
TGC TGT CCC GTC TGC CCC GAC GGC TCA GAG TCA CCC ACC GAC CAA
cys cys pro val cys pro asp gly ser glu ser pro thr asp gln 105
GAA ACC ACC GGC GTC GAG GGA CCC AAG GGA GAC ACT GGC CCC CGA
glu thr thr gly val glu gly pro lys gly asp thr gly pro arg 120
GGC CCA AGG GGA CCC GCA GGC CCC CCT GGC CGA GAT GGC ATC CCT
gly pro arg gly pro ala gly pro pro gly arg asp gly ile pro 135
GGA CAG CCT GGA CTT CCC GGA CCC CCC GGA CCC CCC GGA CCT CCC
gly gln pro gly leu pro gly pro pro gly pro pro gly pro pro 150
GGA CCC CCT GGC CTC GGA GGA AAC TTT GCT CCC CAG CTG TCT TAT
gly pro pro gly leu gly gly asn phe ala pro gln leu ser tyr 165
GGC TAT GAT GAG AAA TCA ACC GGA GGA ATT TCC GTG CCT GGC CCC
gly tyr asp glu lys ser thr gly gly ile ser val pro gly pro 180
ATG GGT CCC TCT GGT CCT CGT GGT CTC CCT GGC CCC CCT GGT GCA
met gly pro ser gly pro arg gly leu pro gly pro pro gly ala 195
CCT GGT CCC CAA GGC TTC CAA GGT CCC CCT GGT GAG CCT GGC GAG
pro gly pro gln gly phe gln gly pro pro gly glu pro gly glu 210
CCT GGA GCT TCA GGT CCC ATG GGT CCC CGA GGT CCC CCA GGT CCC
pro gly ala ser gly pro met gly pro arg gly pro pro gly pro 225
CCT GGA AAG AAT GGA GAT GAT GGG GAA GCT GGA AAA CCT GGT CGT
pro gly lys asn gly asp asp gly glu ala gly lys pro gly arg 240
CCT GGT GAG CGT GGG CCT CCT GGG CCT CAG GGT GCT CGA GGA TTG
pro gly glu arg gly pro pro gly pro gln gly ala arg gly leu 255
CCC GGA ACA GCT GGC CTC CCT GGA ATG AAG GGA CAC AGA GGT TTC
pro gly thr ala gly leu pro gly met lys gly his arg gly phe 270
AGT GGT TTG GAT GGT GCC AAG GGA GAT GCT GGT CCT GCT GGT CCT
ser gly leu asp gly ala lys gly asp ala gly pro ala gly pro 285
AAG GGT GAG CCT GGC AGC CCT GGT GAA AAT GGA GCT CCT GGT CAG
lys gly glu pro gly ser pro gly glu asn gly ala pro gly gln 300
ATG GGC CCC CGT GGC CTG CCT GGT GAG AGA GGT CGC CCT GGA GCC
met gly pro arg gly leu pro gly glu arg gly arg pro gly ala 315
CCT GGC CCT GCT GGT GCT CGT GGA AAT GAT GGT GCT ACT GGT GCT
pro gly pro ala gly ala arg gly asn asp gly ala thr gly ala 330
GCC GGG CCC CCT GGT CCC ACC GGC CCC GCT GGT CCT CCT GGC TTC
ala gly pro pro gly pro thr gly pro ala gly pro pro gly phe 345
CCT GGT GCT GTT GGT GCT AAG GGT GAA GCT GGT CCC CAA GGG CCC
pro gly ala val gly ala lys gly glu ala gly pro gln gly pro 360
CGA GGC TCT GAA GGT CCC CAG GGT GTG CGT GGT GAG CCT GGC CCC
arg gly ser glu gly pro gln gly val arg gly glu pro gly pro 375
CCT GGC CCT GCT GGT GCT GCT GGC CCT GCT GGA AAC CCT GGT GCT
pro gly pro ala gly ala ala gly pro ala gly asn pro gly ala 390
GAT GGA CAG CCT GGT GCT AAA GGT GCC AAT GGT GCT CCT GGT ATT
asp gly gln pro gly ala lys gly ala asn gly ala pro gly ile 405
GCT GGT GCT CCT GGC TTC CCT GGT GCC CGA GGC CCC TCT GGA CCC
ala gly ala pro gly phe pro gly ala arg gly pro ser gly pro 420
CAG GGC CCC GGC GGC CCT CCT GGT CCC AAG GGT AAC AGC GGT GAA
gln gly pro gly gly pro pro gly pro lys gly asn ser gly glu 435
CCT GGT GCT CCT GGC AGC AAA GGA GAC ACT GGT GCT AAG GGA GAG
pro gly ala pro gly ser lys gly asp thr gly ala lys gly glu 450
CCT GGC CCT GTT GGT GTT CAA GGA CCC CCT GGC CCT GCT GGA GAG
pro gly pro val gly val gln gly pro pro gly pro ala gly glu 465
GAA GGA AAG CGA GGA GCT CGA GGT GAA CCC GGA CCC ACT GGC CTG
glu gly lys arg gly ala arg gly glu pro gly pro thr gly leu 480
CCC GGA CCC CCT GGC GAG CGT GGT GGA CCT GGT AGC CGT GGT TTC
pro gly pro pro gly glu arg gly gly pro gly ser arg gly phe 495
CCT GGC GCA GAT GGT GTT GCT GGT CCC AAG GGT CCC GCT GGT GAA
pro gly ala asp gly val ala gly pro lys gly pro ala gly glu 510
CGT GGT TCT CCT GGC CCC GCT GGC CCC AAA GGA TCT CCT GGT GAA
arg gly ser pro gly pro ala gly pro lys gly ser pro gly glu 525
GCT GGT CGT CCC GGT GAA GCT GGT CTG CCT GGT GCC AAG GGT CTG
ala gly arg pro gly glu ala gly leu pro gly ala lys gly leu 540
ACT GGA AGC CCT GGC AGC CCT GGT CCT GAT GGC AAA ACT GGC CCC
thr gly ser pro gly ser pro gly pro asp gly lys thr gly pro 555
CCT GGT CCC GCC GGT CAA GAT GGT CGC CCC GGA CCC CCA GGC CCA
pro gly pro ala gly gln asp gly arg pro gly pro pro gly pro 570
CCT GGT GCC CGT GGT CAG GCT GGT GTG ATG GGA TTC CCT GGA CCT
pro gly ala arg gly gln ala gly val met gly phe pro gly pro 585
AAA GGT GCT GCT GGA GAG CCC GGC AAG GCT GGA GAG CGA GGT GTT
lys gly ala ala gly glu pro gly lys ala gly glu arg gly val 600
CCC GGA CCC CCT GGC GCT GTC GGT CCT GCT GGC AAA GAT GGA GAG
pro gly pro pro gly ala val gly pro ala gly lys asp gly glu 615
GCT GGA GCT CAG GGA CCC CCT GGC CCT GCT GGT CCC GCT GGC GAG
ala gly ala gln gly pro pro gly pro ala gly pro ala gly glu 630
AGA GGT GAA CAA GGC CCT GCT GGC TCC CCC GGA TTC CAG GGT CTC
arg gly glu gln gly pro ala gly ser pro gly phe gln gly leu 645
CCT GGT CCT GCT GGT CCT CCA GGT GAA GCA GGC AAA CCT GGT GAA
pro gly pro ala gly pro pro gly glu ala gly lys pro gly glu 660
CAG GGT GTT CCT GGA GAC CTT GGC GCC CCT GGC CCC TCT GGA GCA
gln gly val pro gly asp leu gly ala pro gly pro ser gly ala 675
AGA GGC GAG AGA GGT TTC CCT GGC GAG CGT GGT GTG CAA GGT CCC
arg gly glu arg gly phe pro gly glu arg gly val gln gly pro 690
CCT GGT CCT GCT GGA CCC CGA GGG GCC AAC GGT GCT CCC GGC AAC
pro gly pro ala gly pro arg gly ala asn gly ala pro gly asn 705
GAT GGT GCT AAG GGT GAT GCT GGT GCC CCT GGA GCT CCC GGT AGC
asp gly ala lys gly asp ala gly ala pro gly ala pro gly ser 720
CAG GGC GCC CCT GGC CTT CAG GGA ATG CCT GGT GAA CGT GGT GCA
gln gly ala pro gly leu gln gly met pro gly glu arg gly ala 735
GCT GGT CTT CCA GGG CCT AAG GGT GAC AGA GGT GAT GCT GGT CCC
ala gly leu pro gly pro lys gly asp arg gly asp ala gly pro 750
AAA GGT GCT GAT GGC TCT CCT GGC AAA GAT GGC GTC CGT GGT CTG
lys gly ala asp gly ser pro gly lys asp gly val arg gly leu 765
ACC GGC CCC ATT GGT CCT CCT GGC CCT GCT GGT GCC CCT GGT GAC
thr gly pro ile gly pro pro gly pro ala gly ala pro gly glu 780
AAG GGT GAA AGT GGT CCC AGC GGC CCT GCT GGT CCC ACT GGA GCT
lys gly glu ser gly pro ser gly pro ala gly pro thr gly ala 795
CGT GGT GCC CCC GGA GAC CGT GGT GAG CCT GGT CCC CCC GGC CCT
arg gly ala pro gly asp arg gly glu pro gly pro pro gly pro 810
GCT GGC TTT GCT GGC CCC CCT GGT GCT GAC GGC CAA CCT GGT GCT
ala gly phe ala gly pro pro gly ala asp gly gln pro gly ala 825
AAA GGC GAA CCT GGT GAT GCT GGT GCC AAA GGC GAT GCT GGT CCC
lys gly glu pro gly asp ala gly ala lys gly asp ala gly pro 840
CCT GGG CCT GCC GGA CCC GCT GGA CCC CCT GGC CCC ATT GGT AAT
pro gly pro ala gly pro ala gly pro pro gly pro ile gly asn 855
GTT GGT GCT CCT GGA GCC AAA GGT GCT CGC GGC AGC GCT GGT CCC
val gly ala pro gly ala lys gly ala arg gly ser ala gly pro 870
CCT GGT GCT ACT GGT TTC CCT GGT GCT GCT GGC CGA GTC GGT CCT
pro gly ala thr gly phe pro gly ala ala gly arg val gly pro 885
CCT GGC CCC TCT GGA AAT GCT GGA CCC CCT GGC CCT CCT GGT CCT
pro gly pro ser gly asn ala gly pro pro gly pro pro gly pro 900
GCT GGC AAA GAA GGC GGC AAA GGT CCC CGT GGT GAG ACT GGC CCT
ala gly lys glu gly gly lys gly pro arg gly glu thr gly pro 915
GCT GGA CGT CCT GGT GAA GTT GGT CCC CCT GGT CCC CCT GGC CCT
ala gly arg pro gly glu val gly pro pro gly pro pro gly pro 930
GCT GGC GAG AAA GGA TCC CCT GGT GCT GAT GGT CCT GCT GGT GCT
ala gly glu lys gly ser pro gly ala asp gly pro ala gly ala 945
CCT GGT ACT CCC GGG CCT CAA GGT ATT GCT GGA CAG CGT GGT GTG
pro gly thr pro gly pro gln gly ile ala gly gln arg gly val 960
GTC GGC CTG CCT GGT CAG AGA GGA GAG AGA GGC TTC CCT GGT CTT
val gly leu pro gly gln arg gly glu arg gly phe pro gly leu 975
CCT GGC CCC TCT GGT GAA CCT GGC AAA CAA GGT CCC TCT GGA GCA
pro gly pro ser gly glu pro gly lys gln gly pro ser gly ala 990
AGT GGT GAA CGT GGT CCC CCC GGT CCC ATG GGC CCC CCT GGA TTG
ser gly glu arg gly pro pro gly pro met gly pro pro gly leu 1005
GCT GGA CCC CCT GGT GAA TCT GGA CGT GAG GGG GCT CCT GCT GCC
ala gly pro pro gly glu ser gly arg glu gly ala pro ala ala 1020
GAA GGT TCC CCT GGA CGA GAC GGT TCT CCT GGC GCC AAG GGT GAC
glu gly ser pro gly arg asp gly ser pro gly ala lys gly asp 1035
CGT GGT GAG ACC GGC CCC GCT GGA CCC CCT GGT GCT CCT GGT GCT
arg gly glu thr gly pro ala gly pro pro gly ala pro gly ala 1050
CCT GGT GCC CCT GGC CCC GTT GGC CCT GCT GGC AAG AGT GGT GAT
pro gly ala pro gly pro val gly pro ala gly lys ser gly asp 1065
CGT GGT GAG ACT GGT CCT GCT GGT CCC GCC GGT CCC GTC GGC CCC
arg gly glu thr gly pro ala gly pro ala gly pro val gly pro 1080
GTC GGC GCC CGT GGC CCC GCC GGA CCC CAA GGC CCC CGT GGT GAC
val gly ala arg gly pro ala gly pro gln gly pro arg gly asp 1095
AAG GGT GAG ACA GGC GAA CAG GGC GAC AGA GGC ATA AAG GGT CAC
lys gly glu thr gly glu gln gly asp arg gly ile lys gly his 1110
CGT GGC TTC TCT GGC CTC CAG GGT CCC CCT GGC CCT CCT GGC TCT
arg gly phe ser gly leu gln gly pro pro gly pro pro gly ser 1125
CCT GGT GAA CAA GGT CCC TCT GGA GCC TCT GGT CCT GCT GGT CCC
pro gly glu gln gly pro ser gly ala ser gly pro ala gly pro 1140
CGA GGT CCC CCT GGC TCT GCT GGT GCT CCT GGC AAA GAT GGA CTC
arg gly pro pro gly ser ala gly ala pro gly lys asp gly leu 1555
AAC GGT CTC CCT GGC CCC ATT GGG CCC CCT GGT CCT CGC GGT CGC
asn gly leu pro gly pro ile gly pro pro gly pro arg gly arg 1170
ACT GGT GAT GCT GGT CCT GTT GGT CCC CCC GGC CCT CCT GGA CCT
thr gly asp ala gly pro val gly pro pro gly pro pro gly pro 1185
CCT GGT CCC CCT GGT CCT CCC AGC GCT GGT TTC GAC TTC AGC TTC
pro gly pro pro gly pro pro ser ala gly phe asp phe ser phe 1200
CTG CCC CAG CCA CCT CAA GAG AAG GCT CAC GAT GGT GGC CGC TAC
leu pro gln pro pro gln glu lys ala his asp gly gly arg tyr 1215
TAC CGG GCT GAT GAT GCC AAT GTG GTT CGT GAC CGT GAC CTC GAG
tyr arg ala asp asp ala asn val val arg asp arg asp leu glu 1230
GTG GAC ACC ACC CTC AAG AGC CTG AGC CAG CAG ATC GAG AAC ATC
val asp thr thr leu lys ser leu ser gln gln ile glu asn ile 1245
CGG AGC CCA GAG GGA AGC CGC AAG AAC CCC GCC CGC ACC TGC CGT
arg ser pro glu gly ser arg lys asn pro ala arg thr cys arg 1260
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