Рис. FBN seq

       Нуклеотидная и аминокислотная последовательности
               гена фибриллина (FBN1) человека

ATG CGT CGA GGG CGT CTG CTG GAG ATC GCC CTG GGA TTT ACC GTG
met arg arg gly arg leu leu glu ile ala leu gly phe thr val   15

CTT TTA GCG TCC TAC ACG AGC CAT GGG GCG GAC GCC AAT TTG GAG
leu leu ala ser tyr thr ser his gly ala asp ala asn leu glu   30

GCT GGG AAC GTG AAG GAA ACC AGA GCC AGT CGG GCC AAG AGA AGA
ala gly asn val lys glu thr arg ala ser arg ala lys arg arg   45

GGC GGT GGA GGA CAC GAC GCG CTT AAA GGA CCC AAT GTC TGT GGA
gly gly gly gly his asp ala leu lys gly pro asn val cys gly   60

TCA CGT TAT AAT GCT TAC TGT TGC CCT GGA TGG AAA ACC TTA CCT
ser arg tyr asn ala tyr cys cys pro gly trp lys thr leu pro   75

GGC GGA AAT CAG TGT ATT GTC CCC ATT TGC CGG CAT TCC TGT GGG
gly gly asn gln cys ile val pro ile cys arg his ser cys gly   90

GAT GGA TTT TGT TCG AGG CCA AAT ATG TGC ACT TGC CCA TCT GGT
asp gly phe cys ser arg pro asn met cys thr cys pro ser gly  105

CAG ATA GCT CCT TCC TGT GGC TCC AGA TCC ATA CAA CAC TGC AAT
gln ile ala pro ser cys gly ser arg ser ile gln his cys asn  120

ATT CGC TGT ATG AAT GGA GGT AGC TGC AGT GAC GAT CAC TGT CTA
ile arg cys met asn gly gly ser cys ser asp asp his cys leu  135

TGC CAG AAA GGA TAC ATA GGG ACT CAC TGT GGA CAA CCT GTT TGT
cys gln lys gly tyr ile gly thr his cys gly gln pro val cys  150

GAA AGT GGC TGT CTC AAT GGA GGA AGG TGT GTG GCC CCA AAT CGA
glu ser gly cys leu asn gly gly arg cys val ala pro asn arg  165

TGT GCA TGC ACT TAC GGA TTT ACT GGA CCC CAG TGT GAA AGA GAT
cys ala cys thr tyr gly phe thr gly pro gln cys glu arg asp  180

TAC AGG ACA GGC CCA TGT TTT ACT GTG ATC AGC AAC CAG ATG TGC
tyr arg thr gly pro cys phe thr val ile ser asn gln met cys  195

CAG GGA CAA CTC AGC GGG ATT GTC TGC ACA AAA CAG CTC TGC TGT
gln gly gln leu ser gly ile val cys thr lys gln leu cys cys  210

GCC ACA GTC GGC CGA GCC TGG GGC CAC CCC TGT GAG ATG TGT CCT
ala thr val gly arg ala trp gly his pro cys glu met cys pro  225

GCC CAG CCT CAC CCC TGC CGC CGT GGC TTC ATT CCA AAT ATC CGC
ala gln pro his pro cys arg arg gly phe ile pro asn ile arg  240

ACG GGA GCT TGT CAA GAT GTG GAT GAA TGC CAG GCC ATC CCC GGG
thr gly ala cys gln asp val asp glu cys gln ala ile pro gly  255

CTC TGT CAG GGA GGA AAT TGC ATT AAT ACT GTT GGG TCT TTT GAG
leu cys gln gly gly asn cys ile asn thr val gly ser phe glu  270

TGC AAA TGC CCT GCT GGA CAC AAA CTT AAT GAA GTG TCA CAA AAA
cys lys cys pro ala gly his lys leu asn glu val ser gln lys  285

TGT GAA GAT ATT GAT GAA TGC AGC ACC ATT CCT GGA ATC TGT GAA
cys glu asp ile asp glu cys ser thr ile pro gly ile cys glu  300

GGG GGT GAA TGT ACA AAC ACA GTC AGC AGT TAC TTT TGC AAA TGT
gly gly glu cys thr asn thr val ser ser tyr phe cys lys cys  315

CCC CCT GGT TTT TAC ACC TCT CCA GAT GGT ACC AGA TGC ATA GAT
pro pro gly phe tyr thr ser pro asp gly thr arg cys ile asp  330

GTT CGC CCA GGA TAC TGT TAC ACA GCT CTG ACA AAC GGG CGC TGC
val arg pro gly tyr cys tyr thr ala leu thr asn gly arg cys  345

TCT AAC CAG CTG CCA CAG TCC ATA ACC AAA ATG CAG TGC TGC TGT
ser asn gln leu pro gln ser ile thr lys met gln cys cys cys  360

GAT GCC GGC CGA TGC TGG TCT CCA GGG GTC ACT GTC GCC CCT GAG
asp ala gly arg cys trp ser pro gly val thr val ala pro glu  375

ATG TGT CCC ATC AGA GCA ACC GAG GAT TTC AAC AAG CTG TGC TCT
met cys pro ile arg ala thr glu asp phe asn lys leu cys ser  390

GTT CCT ATG GTA ATT CCT GGG AGA CCA GAA TAT CCT CCC CCA CCC
val pro met val ile pro gly arg pro glu tyr pro pro pro pro  405

CTT GGC CCC ATT CCT CCA GTT CTC CCT GTT CCT CCT GGC TTT CCT
leu gly pro ile pro pro val leu pro val pro pro gly phe pro  420

CCT GGA CCT CAA ATT CCG GTC CCT CGA CCA CCA GTG GAA TAT CTG
pro gly pro gln ile pro val pro arg pro pro val glu tyr leu  435

TAT CCA TCT CGG GAG CCA CCA AGG GTG CTG CCA GTA AAC GTT ACT
tyr pro ser arg glu pro pro arg val leu pro val asn val thr  450

GAT TAC TGC CAG TTG GTC CGC TAT CTC TGT CAA AAT GGA CGC TGC
asp tyr cys gln leu val arg tyr leu cys gln asn gly arg cys  465

ATT CCA ACT CCT GGG AGT TAC CGG TGT GAG TGC AAC AAA GGG TTC
ile pro thr pro gly ser tyr arg cys glu cys asn lys gly phe  480

CAG CTG GAC CTC CGT GGG GAG TGT ATT GAT GTT GAT GAA TGT GAG
gln leu asp leu arg gly glu cys ile asp val asp glu cys glu  495

AAA AAC CCC TGT GCT GGT GGT GAG TGT ATT AAC AAC CAG GGT TCG
lys asn pro cys ala gly gly glu cys ile asn asn gln gly ser  510

TAC ACC TGT CAG TGC CGA GCT GGA TAT CAG AGC ACA CTC ACG CGG
tyr thr cys gln cys arg ala gly tyr gln ser thr leu thr arg  525

ACA GAA TGC CGA GAC ATT GAT GAG TGT TTA CAG AAT GGC CGG ATC
thr glu cys arg asp ile asp glu cys leu gln asn gly arg ile  540

TGC AAT AAT GGA CGC TGC ATC AAC ACA GAT GGC AGT TTT CAT TGC
cys asn asn gly arg cys ile asn thr asp gly ser phe his cys  555

GTG TGT AAT GCG GGC TTT CAT GTT ACA CGA GAT GGG AAG AAC TGT
val cys asn ala gly phe his val thr arg asp gly lys asn cys  570

GAA GAT ATG GAT GAA TGC AGC ATA AGG AAC ATG TGC CTT AAT GGA
glu asp met asp glu cys ser ile arg asn met cys leu asn gly  585

ATG TGT ATC AAT GAA GAT GGC AGT TTT AAA TGT ATT TGC AAA CCT
met cys ile asn glu asp gly ser phe lys cys ile cys lys pro  600

GGA TTC CAG CTG GCA TCA GAT GGA CGT TAT TGC AAA GAC ATT AAC
gly phe gln leu ala ser asp gly arg tyr cys lys asp ile asn  615

GAG TGT GAA ACC CCT GGG ATC TGC ATG AAT GGG CGT TGC GTC AAC
glu cys glu thr pro gly ile cys met asn gly arg cys val asn  630

ACT GAT GGC TCC TAC AGA TGT GAA TGC TTC CCT GGA CTG GCT GTG
thr asp gly ser tyr arg cys glu cys phe pro gly leu ala val  645

GGT CTG GAT GGC CGT GTG TGT GTT GAC ACA CAC ATG CGG AGC ACA
gly leu asp gly arg val cys val asp thr his met arg ser thr  660

TGC TAT GGT GGA TAC AAG AGA GGC CAG TGT ATC AAA CCT TTG TTT
cys tyr gly gly tyr lys arg gly gln cys ile lys pro leu phe  675

GGT GCT GTC ACT AAA TCT GAA TGC TGT TGC GCC AGC ACT GAG TAT
gly ala val thr lys ser glu cys cys cys ala ser thr glu tyr  690

GCA TTT GGG GAA CCT TGC CAG CCG TGT CCT GCA CAG AAT TCA GCG
ala phe gly glu pro cys gln pro cys pro ala gln asn ser ala  705

GAA TAT CAG GCA CTC TGC AGC AGT GGG CCA GGA ATG ACG TCA GCA
glu tyr gln ala leu cys ser ser gly pro gly met thr ser ala  720

GGC AGT GAT ATA AAT GAA TGT GCA CTA GAT CCT GAT ATT TGC CCA
gly ser asp ile asn glu cys ala leu asp pro asp ile cys pro  735

AAT GGA ATC TGT GAA AAC CTT CGT GGG ACC TAT AAA TGT ATA TGC
asn gly ile cys glu asn leu arg gly thr tyr lys cys ile cys  750

AAT TCA GGA TAT GAA GTG GAT TCA ACT GGG AAA AAC TGC GTT GAT
asn ser gly tyr glu val asp ser thr gly lys asn cys val asp  765

ATT AAT GAA TGT GTA CTG AAC AGT CTC CTT TGT GAC AAT GGA CAA
ile asn glu cys val leu asn ser leu leu cys asp asn gly gln  780

TGT AGA AAT ACT CCT GGA AGT TTT GTC TGT ACC TGC CCC AAG GGA
cys arg asn thr pro gly ser phe val cys thr cys pro lys gly  795

TTT ATC TAC AAA CCT GAT CTA AAA ACA TGT GAA GAC ATT GAT GAA
phe ile tyr lys pro asp leu lys thr cys glu asp ile asp glu  810

TGC GAA TCA AGT CCT TGC ATT AAT GGA GTC TGC AAG AAC AGC CCA
cys glu ser ser pro cys ile asn gly val cys lys asn ser pro  825

GGC TCT TTT ATT TGT GAA TGT TCT TCT GAA AGT ACT TTG GAT CCA
gly ser phe ile cys glu cys ser ser glu ser thr leu asp pro  840

ACA AAA ACC ATC TGC ATA GAA ACC ATC AAG GGC ACT TGC TGG CAG
thr lys thr ile cys ile glu thr ile lys gly thr cys trp gln  855

ACT GTC ATT GAT GGG CGA TGT GAG ATC AAC ATC AAT GGA GCC ACC
thr val ile asp gly arg cys glu ile asn ile asn gly ala thr  870

TTA AAG TCC CAG TGC TGC TCC TCC CTC GGT GCT GCG TGG GGA AGC
leu lys ser gln cys cys ser ser leu gly ala ala trp gly ser  885

CCG TGC ACC CTA TGC CAA GTT GAT CCC ATA TGT GGT AAA GGG TAC
pro cys thr leu cys gln val asp pro ile cys gly lys gly tyr  900

TCA AGA ATT AAA GGA ACA CAA TGT GAA GAT ATA GAT GAA TGT GAA
ser arg ile lys gly thr gln cys glu asp ile asp glu cys glu  915

GTG TTC CCA GGA GTG TGT AAA AAT GGC CTG TGT GTT AAC ACT AGG
val phe pro gly val cys lys asn gly leu cys val asn thr arg  930

GGG TCA TTC AAG TGT CAG TGT CCC AGT GGA ATG ACT TTG GAT GCC
gly ser phe lys cys gln cys pro ser gly met thr leu asp ala  945

ACA GGA AGG ATC TGT CTT GAT ATC CGC CTG GAA ACC TGC TTC CTG
thr gly arg ile cys leu asp ile arg leu glu thr cys phe leu  960

AGG TAC GAG GAC GAG GAG TGC ACC CTG CCT ATT GCT GGC CGC CAC
arg tyr glu asp glu glu cys thr leu pro ile ala gly arg his  975

CGC ATG GAC GCC TGC TGC TGC TCC GTC GGG GCA GCC TGG GGT ACT
arg met asp ala cys cys cys ser val gly ala ala trp gly thr  990

GAG GAA TGC GAG GAG TGT CCC ATG AGA AAT ACT CCT GAG TAC GAG
glu glu cys glu glu cys pro met arg asn thr pro glu tyr glu 1005

GAG CTG TGT CCG AGA GGA CCC GGA TTT GCC ACA AAA GAA ATT ACA
glu leu cys pro arg gly pro gly phe ala thr lys glu ile thr 1020

AAT GGA AAG CCT TTC TTC AAA GAT ATC AAT GAG TGC AAG ATG ATA
asn gly lys pro phe phe lys asp ile asn glu cys lys met ile 1035

CCC AGC CTC TGC ACC CAC GGC AAG TGC AGA AAC ACC ATT GGC AGC
pro ser leu cys thr his gly lys cys arg asn thr ile gly ser 1050

TTT AAG TGC AGG TGT GAC AGC GGC TTT GCT CTT GAT TCT GAA GAA
phe lys cys arg cys asp ser gly phe ala leu asp ser glu glu 1065

AGG AAC TGC ACA GAC ATT GAC GAA TGC CGC ATA TCT CCT GAC CTC
arg asn cys thr asp ile asp glu cys arg ile ser pro asp leu 1080

TGT GGC AGA GGC CAG TGT GTG AAC ACC CCT GGG GAC TTT GAA TGC
cys gly arg gly gln cys val asn thr pro gly asp phe glu cys 1095

AAG TGT GAC GAA GGC TAT GAA AGT GGA TTC ATG ATG ATG AAG AAC
lys cys asp glu gly tyr glu ser gly phe met met met lys asn 1110

TGC ATG GAT ATT GAT GAG TGT CAG AGA GAT CCT CTC CTA TGC CGA
cys met asp ile asp glu cys gln arg asp pro leu leu cys arg 1125

GGT GGT GTT TGC CAT AAC ACA GAG GGA AGT TAC CGC TGT GAA TGC
gly gly val cys his asn thr glu gly ser tyr arg cys glu cys 1140

CCG CCT GGC CAT CAG CTG TCC CCC AAC ATC TCC GCG TGT ATC GAC
pro pro gly his gln leu ser pro asn ile ser ala cys ile asp 1155

ATC AAT GAA TGT GAG CTG AGT GCA CAC CTG TGC CCC AAT GGC CGT
ile asn glu cys glu leu ser ala his leu cys pro asn gly arg 1170

TGC GTG AAC CTC ATA GGG AAG TAT CAG TGT GCC TGC AAC CCT GGC
cys val asn leu ile gly lys tyr gln cys ala cys asn pro gly 1185

TAC CAT TCA ACT CCC GAT AGG CTA TTT TGT GTT GAC ATT GAT GAA
tyr his ser thr pro asp arg leu phe cys val asp ile asp glu 1200

TGC AGC ATA ATG AAT GGT GGT TGT GAA ACC TTC TGC ACA AAC TCT
cys ser ile met asn gly gly cys glu thr phe cys thr asn ser 1215

GAA GGC AGC TAT GAA TGT AGC TGT CAG CCG GGA TTT GCA CTA ATG
glu gly ser tyr glu cys ser cys gln pro gly phe ala leu met 1230

CCT GAC CAG AGA TCA TGC ACC GAC ATC GAT GAG TGT GAA GAT AAT
pro asp gln arg ser cys thr asp ile asp glu cys glu asp asn 1245

CCC AAT ATC TGT GAT GGT GGT CAG TGC ACA AAT ATC CCT GGA GAG
pro asn ile cys asp gly gly gln cys thr asn ile pro gly glu 1260

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