Рис. PI seq
Нуклеотидная и аминокислотная последовательности гена
альфа-1-антитрипсина (AAT) [ингибитора протеазы 1 (PI)]
человека
-23
ATG CCG TCT TCT GTC TCG TGG GGC ATC CTC CTG GCA GGC CTG TGC
met pro ser ser val ser trp gly ile leu leu ala gly leu cys 15
+1
TGC CTG GTC CCT GTC TCC CTG GCT GAG GAT CCC CAG GGA GAT GCT
cys leu val pro val ser leu ala glu asp pro gln gly asp ala 30
GCC CAG AAG ACA GAT ACA TCC CAC CAT GAT CAG GAT CAC CCA ACC
ala gln lys thr asp thr ser his his asp gln asp his pro thr 45
TTC AAC AAG ATC ACC CCC AAC CTG GCT GAG TTC GCC TTC AGC CTA
phe asn lys ile thr pro asn leu ala glu phe ala phe ser leu 60
TAC CGC CAG CTG GCA CAC CAG TCC AAC AGC ACC AAT ATC TTC TTC
tyr arg gln leu ala his gln ser asn ser thr asn ile phe phe 75
TCC CCA GTG AGC ATC GCT ACA GCC TTT GCA ATG CTC TCC CTG GGG
ser pro val ser ile ala thr ala phe ala met leu ser leu gly 90
ACC AAG GCT GAC ACT CAC GAT GAA ATC CTG GAG GGC CTG AAT TTC
thr lys ala asp thr his asp glu ile leu glu gly leu asn phe 105
AAC CTC ACG GAG ATT CCG GAG GCT CAG ATC CAT GAA GGC TTC CAG
asn leu thr glu ile pro glu ala gln ile his glu gly phe gln 120
GAA CTC CTC CGT ACC CTA AAC CAG CCA GAC AGC CAG CTC CAG CTG
glu leu leu arg thr leu asn gln pro asp ser gln leu gln leu 135
ACC ACC GGC AAT GGC CTG TTC CTC AGC GAG GGC CTG AAG CTA GTG
thr thr gly asn gly leu phe leu ser glu gly leu lys leu val 150
GAT AAG TTT TTG GAG GAT GTT AAA AAG TTG TAC CAC TCA GAA GCC
asp lys phe leu glu asp val lys lys leu tyr his ser glu ala 165
TTC ACT GTC AAC TTC GGG GAT CAC GAA GAG GCC AAG AAA CAG ATC
phe thr val asn phe gly asp his glu glu ala lys lys gln ile 180
AAC GAT TAC GTG GAG AAG GGT ACT CAA GGG AAA ATT GTG GAT TTG
asn asp tyr val glu lys gly thr gln gly lys ile val asp leu 195
GTC AAG GAG CTT GAC AGA GAC ACA GTT TTT GCT CTG GTG AAT TAC
val lys glu leu asp arg asp thr val phe ala leu val asn tyr 210
ATC TTC TTT AAA GGC AAA TGG GAG AGA CCT TTT GAA GTC AAG GAC
ile phe phe lys gly lys trp glu arg pro phe glu val lys asp 225
ACC GAG GAC GAG GAC TTC CAC GTG GAC CAG GTG ACC ACC GTG AAG
thr glu asp glu asp phe his val asp gln val thr thr val lys 240
GTC CCT ATG ATG AAG CGT TTA GGC ATG TTT AAC ATC CAG CAC TGT
val pro met met lys arg leu gly met phe asn ile gln his cys 255
AAG AAG CTG TCC AGC TGG GTA CTG CTA ATG AAA TAC CTG GGC AAT
lys lys leu ser ser trp val leu leu met lys tyr leu gly asn 270
GCC ACC GCC ATC TTC TTC CTA CCT GAT GAG GGG AAA CTA CAG CAC
ala thr ala ile phe phe leu pro asp glu gly lys leu gln his 285
CTG GAA AAT GAA CTC ACC CAC GAT ATC ATC ACC AAG TTC CTG GAA
leu glu asn glu leu thr his asp ile ile thr lys phe leu glu 300
AAT GAA GAC AGA AGG TCT GCC AGC TTA CAT TTA CCC AAA CTG TCC
asn glu asp arg arg ser ala ser leu his leu pro lys leu ser 315
ATT ACT GGA ACC TAT GAT CTG AAG AGC GTC CTG GGT CAA CTG GGC
ile thr gly thr tyr asp leu lys ser val leu gly gln leu gly 330
ATC ACT AAG GTC TTC AGC AAT GGG GCT GAC CTC TCC GGG GTC ACA
ile thr lys val phe ser asn gly ala asp leu ser gly val thr 345
GAG GAG GCA CCC CTG AAG CTC TCC AAG GCC GTG CAT AAG GCT GTG
glu glu ala pro leu lys leu ser lys ala val his lys ala val 360
CTG ACC ATC GAC GAG AAG GGG ACT GAA GCT GCT GGG GCC ATG TTT
leu thr ile asp glu lys gly thr glu ala ala gly ala met phe 375
TTA GAG GCC ATA CCA ATG TCT ATC CCC CCA GAG GTC AAG TTC AAC
leu glu ala ile pro met ser ile pro pro glu val lys phe asn 390
AAA CCC TTT GTC TTC TTA ATG ATT GAA CAA AAT ACC AAG TCT CCC
lys pro phe val phe leu met ile glu gln asn thr lys ser pro 405
CTC TTC ATG GGA AAA GTG GTG AAT CCC ACC CAA AAA TAA
leu phe met gly lys val val asn pro thr gln lys ter
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