Gene: [02p241/MYCN] avian myelocytomatosis viral related oncogene; [NMYC]

FAG

MYCN is a component of the multigene family of MYC protooncogenes (see GEM:08q241/MYC)."

TIS

Relatively tissue-specific, intensive expression is characteristic for MYCN (in contrast to MYC1). This is related to either pronounced amplification of the locus (predominantly in tumors that are developed from primitive cells, e.g., in neuroblastomas) or enhanced expression without amplification (as is the case for developing kidney or for Wilms tumor)."

EXP

MYCN amplification in neuroblastomas reflects a pronounced progression of tumor and increasing metastatic spreading. It is important that the amplificated copies of MYCN are found most frequently in other chromosomes rather than the standard locus of the unique gene on chr 2p."

GEN

The gene length is 6.6 kb. Exons: 3; the first of them, in the 5'-region of the processed transcript, is not translated; the second and third exons code for the protein with MM 49 kD consisting of 456 amino acid residues."

REF

REV,GEN,EVO "Alt &: Cold Spring Harbor Symp, 51, (Part 2), 931-941, 1986
EXP,PAT,CYG "Brodeur GM, Seeger: Cancer Genet Cytogenet, 19, 101-111, 1986
EXP,PAT,CYG "Brodeur GM &: Science, 224, 1121-1124, 1984
EXP,PAT,CYG "Christiansen &: Cancer Genet Cytogenet, 26, 235-244, 1987
EXP,PAT,CYG "Emanuel &: PNAS, 82, (Jun), 3736-3740, 1985
EXP,PAT,CYG "Garson JA &: CCG, 45, 10-15, 1987a
PRO,LOC "Garson JA &: NAR, 15, 4761-4770, 1987b
PRO,LOC "Kanda N &: PNAS, 80, 4069-4073, 1983
MUT,MOL,PAT,FAG "Kato &: FEBS Lett, 250, N2, 529-535, 1989
EXP,PAT,CYG "Kinzler KW &: PNAS, 83, N4, 1031-1035, 1986
GEN,SEQ,MOP "Kohl NE &: Nature, 319, 73-77, 1986
EXP,PAT,CYG "Kohl NE &: Science, 226, 1335-1337, 1984
EXP,PAT,CYG "Kohl NE &: Cell, 35, 359-367, 1983
EXP,PAT,CYG "Lee &: Nature, 309, 458-460, 1984
GEN,SEQ,MOP "Michitsch RW, Melera: NAR, 13, 2545-2558, 1985
GEN,SEQ,MOP "Ramsay &: Mol Cell Biol, 6, 4450-4457, 1986
EXP,PAT,CYG "Schwab M: Trends Genet, 1, 271-275, 1985
PRO,LOC "Schwab M &: Nature, 308, (15 Mar), 288-291, 1984a
EXP,PAT,CYG "Schwab M &: PNAS, 81, 4940-4944, 1984b
EXP,PAT,CYG "Schwab M &: Nature, 305, (15 Sep), 245-248, 1983
EXP,PAT,CYG "Seeger &: New Engl J Med, 313, 1111-1116, 1985
EXP,PAT,CYG "Shiloh Y &: PNAS, 82, 3761-3765, 1985
GEN,SEQ,MOP "Stanton LW &: PNAS, 83, N6, 1772-1776, 1986
EXP,PAT,CYG "Thiele &: Nature, 313, (31 Jan), 404-406, 1985
EXP,PAT,CYG "Zehnbauer &: Mol Cell Biol, 8, N2, 522-530, 1988

SWI

SWISSPROT: P04198

KEY

onc

CLA

coding, basic

LOC

02 p24.1

MIM

MIM: 164840

SYN

NMYC

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