Gene: [02q1/GLC1B] glaucoma 1, open angle, B (adult-onset); [POAG ]

COM

The GLC1B locus is positioned to a region of 11.2 cM that is flanked by D2S2161 and D2S176 (Stoilova-1996)."

PAT

Primary open angle glaucoma is a common ocular disorder with a characteristic degeneration of the optic nerve and visual field defects that is often associated with an elevated intraocular pressure (Stoilova-1996)."

HET

Five forms of adult-onset primary open angle glaucoma had been distinguished by linkage studies: GLC1B, mapped to chromosome 2 (GEM:02q1/GLC1B); GLC1C, mapped to chromosome 3 (GEM:03q2/GLC1C); GLC1D, mapped to 8q23 (GEM:08q23/GLC1D); GLC1E, mapped to 10p15-p14 (GEM:10p1/GLC1E); and GLC1F, not mapped yet (GEM:00.0/GLC1F)."

REF

LOC,LIN,PAT "Stoilova D &: Genomics, 36, 142-150, 1996

KEY

eye

CLA

unknown, basic

LOC

02 q11-13

MIM

MIM: 137760

SYN

POAG

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