Gene: [02q33/PLCE] phospholipase C, epsilon (lung carcinoma-related); lung carcinoma?;
|
COM |
Kohno et al. constructed a cosmid contig covering the homozygous deleted region at 2q33, estimated at 220 kb, and identified a gene from the deleted region; all of the coding exons of this gene were homozygously deleted in the cell line, while a 5-prime-noncoding exon was retained (Kohno-1995)." |
|
ASS |
The aberrant expression of the PLCE gene is suggested to contribute to the genesis of progression of human lung carcinoma since PLCL sequence homology to phospholipase C genes suggested the involvement of the PLCL gene in an inositol phospholipid-based intracellular signaling cascade. However, its expression was greatly reduced in 7 of 13 (53.8%) of small cell lung carcinoma and 13 of 15 (86.7%) of non small-cell lung carcinoma cell lines (Kohno-1995)." |
|
REF |
COD,SEQ,ABR,LOC,ASS,EXP "Kohno T &: Hum Mol Genet, 4, N4, 667-674,
1995 ABR,CLO,LOC "Otsuka &: Genes Chromosom Cancer, 16, N2, 113-119, 1996 |
|
KEY |
lip, onc |
|
CLA |
coding, basic |
|
LOC |
02 q33 |
|
MIM |
MIM: 600597 |
|
EZN |
ENZYME: 3.1.4.11? |
