Gene: [03p2/SCLC] small cell lung cancer; [SCCL SCLC1 ]

COM

This marker was excluded from the HGM10 catalogue, since its independence is not proved. The gene was localized by presumption to chromosome 3, on the basis of exlusively cytogenetic data (the phenomenon of loss of constitutional heterozygosity was used, that caused the clonal expression of the hypothetic recessive mutation leading to malignancy in hemizygotic cells). However, in this subsegment the protooncogene ERB-A2 (the gene for beta receptor of the thyroid hormone, GEM:03p243/THRB) is located, which is probably involved in pathogenesis of the small cell lung cancer (in a number of such tumors the loss of ERB-A2 gene was revealed by the direct method of the DNA probe diagnosis)."

FAG

The SCLC gene is likely to interact with a fragile site FRA3B in which the frequency of aberrations is increased in small cell lung cancer (Liu-1989)."

REF

IDN,PHE,PAT "Baylin &: PNAS, 79, 4650-4654, 1982
LOC "Brauch &: New Engl J Med, 317, 1109-1113, 1987
IDN,PHE,PAT "De Leij &: Cancer Res, 45, 6024-6033, 1985
LOC "Falor WH &: Cancer Genet Cytogenet, 16, 175-177, 1985
LOC "Graziano SL &: Cancer Res, 47, 2148-2155, 1987
LOC "Kok K &: Nature, 330, 578-581, 1987
PAT,FOG,LIN,CYG,REL "Liu CX &: Cancer Genet Cytogenet, 42, 107-114, 1989
LOC "Mooibroek H &: Cancer Genet Cytogenet, 27, 361-365, 1987
LOC "Naylor SL &: Nature, 329, 451-454, 1987
LOC "Naylor SL &: AJHG, 36, S35, 1984
IDN,PHE,PAT "Ruff &: Science, 225, 1034-1036, 1984
LOC "Whang-Peng J &: Cancer Genet Cytogenet, 6, 119-134, 1982a
LOC "Whang-Peng J &: Science, 215, 181-182, 1982b
LOC "Yokota J &: PNAS, 84, N24, 9252-9256, 1987

KEY

onc, pulm

CLA

unknown, basic

LOC

03 p23-21

MIM

MIM: 182280

SYN

SCCL SCLC1

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