Gene: [04p14/UCHL1] ubiquitin carboxyl-terminal esterase L1 (neuron-specific);

FUN

[1] Ubiquitin carboxyl-terminal esterase is involved in the processing of ubiquitin precursors and ubiquinated proteins. This enzyme is a thiol protease that recognizes and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin.
[2] The catalyzed reaction: ubiquitin c-terminal thiolester + H(2)O = ubiquitin + a thiol."

TIS

Ubiquitin carboxyl-terminal esterase is expressed in neurons and cells of the diffuse neuroendocrine system and the respective tumours. 0.5 to 1% of this fraction is accounted for by soluble brain proteins."

REF

GEN "Day INM &: Biochem J, 268, 521-524, 1990
CLO,COD "Day INM &: FEBS Lett, 210, 157-160, 1987
MEB,EXP "Doran &: J Neurochem, 40, 1542-1547, 1983
LOC,FAG "Edwards &: CCG, 58, (HGM11), 1886-1887, 1991

SWI

SWISSPROT: P09936

KEY

neu, pep

CLA

coding, basic

LOC

04 p14

MIM

MIM: 191342

EZN

ENZYME: 3.1.2.15

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