Gene: [04p14/UCHL1] ubiquitin carboxyl-terminal esterase L1 (neuron-specific);
FUN | [1]
Ubiquitin carboxyl-terminal esterase is involved in the processing of
ubiquitin precursors and ubiquinated proteins. This enzyme is a thiol
protease that recognizes and hydrolyses a peptide bond at the C-terminal
glycine of ubiquitin. [2] The catalyzed reaction: ubiquitin c-terminal thiolester + H(2)O = ubiquitin + a thiol." |
TIS | Ubiquitin carboxyl-terminal esterase is expressed in neurons and cells of the diffuse neuroendocrine system and the respective tumours. 0.5 to 1% of this fraction is accounted for by soluble brain proteins." |
REF | GEN "Day
INM &: Biochem J, 268, 521-524, 1990 CLO,COD "Day INM &: FEBS Lett, 210, 157-160, 1987 MEB,EXP "Doran &: J Neurochem, 40, 1542-1547, 1983 LOC,FAG "Edwards &: CCG, 58, (HGM11), 1886-1887, 1991 |
SWI | SWISSPROT: P09936 |
KEY | neu, pep |
CLA | coding, basic |
LOC | 04 p14 |
MIM | MIM: 191342 |
EZN | ENZYME: 3.1.2.15 |
