Gene: [04q1/JPD] periodontitis, juvenile; [JP AP ]

HET

[1] The MIM catalogue describes several types of periodontitis: the dominant type (JP, juvenile, with local gingiva atrophy around incisors and first molar teeth), a recessive form (AP, MIM:260950, with later onset and more generalized pathological process) and a X-linked periodontosis (MIM:311750). However, baring in mind the data of Long-1987 about the combined inheritance of these two forms in some families, one cannot exclude their allelism.
[2] In some families, linkage of JPD to GC (group-specific protein) in chromosome 4q with the concurrent independent inheritance of JPD and DGI (dentinogenesis imperfecta), were found. At the same time, GC is likely to be located between JPD and DGI. However, both JPD and DGI are possibly related to the statherin gene (GEM:04q1/STATH)."

REF

PHE,FOG "Beaty &: AJHG, 40, 443-452, 1987
LOC,LIN "Boughman JA &: J Craniofac Genet Dev Biol, 6, 341-350, 1986
PHE,FOG "Long &: Genet Epidemiol, 4, 13-24, 1987
LOC,LIN "Marazita &: CCG, 51, (HGM10), 1039, 1989
PHE,FOG "Rao &: Am J Med Genet, 4, 39-45, 1979
LOC,LIN "Roulston &: AJHG, 37, A206, 1985
PHE,FOG "Saxen, Nevanlinna: Clin Genet, 25, 332-335, 1984

KEY

dent

CLA

unknown, basic

LOC

04 q1

MIM

MIM: 170650

SYN

JP AP

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