Gene: [04q1/JPD] periodontitis, juvenile; [JP AP ]
|
HET |
[1] The MIM catalogue describes several types of periodontitis: the
dominant type (JP, juvenile, with local gingiva atrophy around incisors and
first
molar teeth), a recessive form (AP, MIM:260950, with later
onset and more generalized pathological process) and a X-linked
periodontosis (MIM:311750). However,
baring in mind the data of Long-1987 about the combined inheritance of
these two forms in some families, one cannot exclude their allelism.
[2] In some families, linkage of JPD to GC (group-specific protein) in chromosome 4q with the concurrent independent inheritance of JPD and DGI (dentinogenesis imperfecta), were found. At the same time, GC is likely to be located between JPD and DGI. However, both JPD and DGI are possibly related to the statherin gene (GEM:04q1/STATH)." |
|
REF |
PHE,FOG "Beaty &: AJHG, 40, 443-452, 1987 LOC,LIN "Boughman JA &: J Craniofac Genet Dev Biol, 6, 341-350, 1986 PHE,FOG "Long &: Genet Epidemiol, 4, 13-24, 1987 LOC,LIN "Marazita &: CCG, 51, (HGM10), 1039, 1989 PHE,FOG "Rao &: Am J Med Genet, 4, 39-45, 1979 LOC,LIN "Roulston &: AJHG, 37, A206, 1985 PHE,FOG "Saxen, Nevanlinna: Clin Genet, 25, 332-335, 1984 |
|
KEY |
dent |
|
CLA |
unknown, basic |
|
LOC |
04 q1 |
|
MIM |
MIM: 170650 |
|
SYN |
JP AP |
