Gene: [04q1/STATH] statherin (salivary protein); [STR SPFSTAT ]

ASS

The protein suppresses intensively the crystal growth and precipitation of calcium phosphates; the deterioration of its functions may cause the dentin pathology. The dentinogenesis imperfecta and periodontitis (GEM:04q1/DGI and GEM:04q1/JPD, respectively) were mapped to chromosome 4q independently (on the basis of linkage with vitamin D binding protein, GEM:04q1/GC, and of recombination with each other). Taking all this into account, the MIM catalogue does not exclude that DGI and JPD are in fact allelic variants of the STATH gene."

FAG

Although the main salivary protein gene cluster is located in Chr 12p (see FAM:SPF12P/12p132), genes for a number of other proteins with similar functions are mapped in Chr 4 (see GEM:04q13/HTN1)."

REF

PRO,COD,SEQ,EVO "Dickinson DP &: BBRC, 149, 784-790, 1987
PRO,COD,SEQ,LOC,MOL "Sabatini LM &: AJHG, 41, 1048-1060, 1987
PRO,COD,SEQ,LOC,MOL "Sabatini LM &: AJHG, 39, A217, 1986

SWI

SWISSPROT: P02808

KEY

dent, ion

CLA

coding, basic

LOC

04 q1

MIM

MIM: 184470

SYN

STR SPFSTAT