Gene: [04q31/UCP1] uncoupling protein 1 (mitochondrial, proton carrier); brown adipose tissue uncoupling protein (thermogenin);
FUN | The mitochondrial uncoupling protein plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial membrane in brown adipose tissue, without coupling to any other energy-consuming process." |
REL | GEM:11q13/UCP2; GEM:11q13/UCP3. |
REF | GEN,EXP "Bouillaud F
&: Clin Sci, 75, 21-27, 1988 CLO,SEQ,STR,LOC "Cassard AM &: J Cell Biochem, 43, 255-264, 1990 CLO,SEQ "Ceci JD &: Genomics, 6, 72-79, 1990 FUN "Dib C &: Nature, 380, 152-154, 1996 MOD,MOU,FUN,PHE "Enerback S &: Nature, 387, 90-93, 1997 HET,FUN "Fleury C &: Nature Genet, 15, 269-272, 1997 FUN "Goold RD &: Hum Mol Genet, 2, 1271-1288, 1993 CLO "Jacobsson A &: JBC, 260, 16250-16254, 1985 |
SWI | SWISSPROT: P25874 |
KEY | mito |
CLA | coding, basic |
LOC | 04 q31 |
MIM | MIM: 113730 |
