Gene: [11q13/UCP3] uncoupling protein 3 (mitochondrial, proton carrier);
|
COM |
Boss-1998 assigned the UCP3 gene to Chr 11q13. |
|
FUN |
[1] The mitochondrial uncoupling protein plays an important role in
generating
heat; see details in GEM:04q31/UCP1.
[2] Boss-1997 examined UCP expression in cold-adapted rats and found that, unlike UCP1, the expression levels of UCP2 (GEM:11q13/UCP2) and UCP3 were not affected by cold. Nonetheless, the authors concluded that UCP3 may be involved in thermogenesis through the uncoupling of oxidative phosphorylation in skeletal muscle." |
|
MOP |
Boss et al. cloned a short isoform of UCP3 (UCP3S) having 275 amino acids, and a long isoform of UCP3 (UCP3L), having 312 amino acids. UCP3S contained 3 mitochondrial energy-transfer-protein domains and 5 putative transmembrane domains, while UCP3L contained an additional 37 amino acids at its C terminus that encoded a putative transmembrane domain and a putative purine nucleotide-binding domain (Boss-1997)." |
|
TIS |
UCP3 is expressed preferentially and abundantly in skeletal muscle and brown adipose tissue (Vidal-Puig-1997) and in heart (Boss-1997)." |
|
REF |
CLO,SEQ,GEN,LOC "Boss O &: Genomics, 47, N3, 425-426, 1998 COD,SEQ,DOM,HET,FUN "Boss O &: FEBS Lett, 408, 39-42, 1997 COD,EXP,TIS "Vidal-Puig A &: BBRC, 235, N1, 79-82, 1997 |
|
KEY |
mito, ion |
|
CLA |
coding, basic |
|
LOC |
11 q13 |
|
MIM |
MIM: 602044 |
