Gene: [04q/PF4] platelet factor 4;

MOP

The protein contains 70 amino acid residues.

TIS

Factor PF4 is secreted from the alpha granules of activated platelets."

FUN

Factor PF4 binds heparin, locally inhibits antithrombin III, and neutralizes heparin-like substances on the surface of vascular endothelium."

EVO

Factor PF4 shares homology with other platelet-secreted proteins: beta-thromboglobulin (GEM:04q1/PPBP), interferon-inducible cytokine IP10 (GEM:04q21/IFNI10), and melanoma growth stimulating factor (GEM:04q21/GRO1)."

PRO

Probe pF4 contains a 1.4-kb gDNA fragment cloned in M13MP18 phage and covering two-thirds of the 3'-region of PF4 gene."

REL

GEM:04q/PF4V1.

REF

LOC,MOL,PRO "Griffin CA &: CCG, 45, 67-69, 1987
POL,MOL "Guzzo C &: NAR, 15, 380, 1987
CLO,SEQ,EXP,EVO "Poncz M &: Blood, 69, 219-223, 1987

SWI

 SWISSPROT: P02776

KEY

hem, clot

CLA

coding, basic

LOC

04 q12-21

MIM

 MIM: 173460