Gene: [04q21/GRO1] oncogene GRO1 (GRO-alpha; melanoma growth stimulating activity); neutrophil-activating protein 3; [GRO NAP3 MGSA ]

COM

The location 4q21 is indicated on the basis of data (Buetow-1989) on the complete linkage of GRO1 (MGSA) with the gene of gamma-interferon-inducible protein IP10, wich was previously mapped to q21 (GEM:04q21/IFNI10). Richmond-1988, studying the in situ hybridization of gene-specific probe on chromosomes, demonstrated that a significant peak of hybridization signal corresponds to subsegment q13, which is the nearest one to q21 (from the centromere side)."

EVO

The melanoma growth factor is highly homologous to the protein IP10 and the group of peptides involved in the inflammatory responses (IRP, Inflammatory Response Peptides). The IRP group includes, in particular, platelet factor 4 (GEM:04q/PF4) and pro-platelet basic protein (PPBP), which is the precursor of the peptide CTAP III and beta-thromboglobulin (GEM:04q1/PPBP; see also Holt-1986)."

FAG

GRO oncogenes (see also GEM:04q21/GRO2 and GEM:04q21/GRO3) belong to small inducible cytokines B - cytokine subfamily with C-X-C motif."

REF

PRO,SEQ,EXP,EVO "Anisowicz A &: PNAS, 85, N24, 9645-9649, 1988
PRO,SEQ,EXP,EVO "Anisowicz A &: PNAS, 84, N20, 7188-7192, 1987
PRO,SEQ,EXP,EVO "Baker NE &: NAR, 18, 6453, 1990
PRO,SEQ,EXP,EVO "Buetow KH &: AJHG, 48, 911-925, 1991
MAG,LOC,POL "Buetow KH &: CCG, 51, (HGM10), 973, 1989
PRO,SEQ,EXP,EVO "Fairbrother WJ &: J Mol Biol, 242, 252-270, 1994
PRO,SEQ,EXP,EVO "Fairbrother WJ &: FEBS Lett, 330, 302-306, 1993
PRO,SEQ,EXP,EVO "Goold RD &: Hum Mol Genet, 2, 1271-1288, 1993
PRO,SEQ,EXP,EVO "Haskill S &: PNAS, 87, 7732-7736, 1990
FAG,EAG,EVO "Holt JC &: Biochemistry, 25, 1988-1996, 1986
IDN,FUN "Richmond A, Thomas: J Cell Biochem, 36, 185-198, 1988a
PRO,SEQ,EXP,FUN,EVO,LOC "Richmond A &: EMBO J, 7, N7, 2025-2033, 1988b
IDN,FUN "Richmond A &: J Invest Derm, 86, 295-302, 1986
IDN,FUN "Richmond A &: Cancer Res, 45, 6390-6394, 1985
IDN,FUN "Richmond A &: Cancer Res, 42, 3175-3180, 1982
MAG,LOC,POL "Sakaguchi AY &: CCG, 51, (HGM10), 1072, 1989

SWI

SWISSPROT: P09341

KEY

onc, derm, cyk

CLA

coding, basic

LOC

04 q21

MIM

MIM: 155730

SYN

GRO NAP3 MGSA

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