Gene superfamily: small inducible cytokines; (@SCYA @SCYB SCYC1 SCYC2 SCYD1)
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SUM |
[1] Several members belong to the family of inflammatory polypeptides
which are expressed after cellular activation. The corresponding genes
have been cloned and studied. The family has been divided into two
distinct subfamilies based on a characteristic motif which is formed by
the first two cysteine residues in the mature proteins: all members of
the SCY-A group have two adjacent cysteines (the Cys-Cys, or CC gene
family), whereas the SCY-B group comprises inflammatory cytokines with
a single amino acid separating those cysteine residues (the Cys-any-Cys,
or CXC gene family).
[2] It is an interesting fact that several members of the latter family have been mapped to chromosome 4 (see GEM:04q21/GRO1) and are shown to be in a tight linkage each with other, whereas all known human genes of the CC family have been assigned to chromosome region 17q112 with the exception of A11 (GEM:17q21/SCYA11). Based on the facts and data on comparative mapping of the murine CC family genes mouse Chr 11 (that is an evolutionary homeologue of human Chr 17) it could be expected that all of the human SCYA genes may be in a tight linkage each with other and reside in the same chromosome subsegment." |
