Gene: [06q253/IGF2R] insulin-like growth factor 2 receptor; somatomedin A receptor (IGF2 receptor); mannose 6-phosphate receptor, cation-independent; [MPRI MPRCI ]

FUN

The cation-independent (M6PRI) form of MAN-6-P receptor binds lysosomal hydrolases that penetrate into cell by endocytosis. See also GEM:12p13/M6PRD."

EVO

Sequencing of the gene revealed that the cation-independent receptor, M6PRI, is almost identical to the IGF2R receptor for insulin-like cytokin II
(99.4% by the amino acid sequence and 99.8% by the nucleotide one)."

FAG

The gene for the cation-dependent form (GEM:12p13/M6PRD) have been mapped and sequenced. This form provides binding of intracellular lysosomal hydrolases."

REF

FUN,PEP,EXP "Brown &: J Cell Biol, 103, 1235-1247, 1986
REV,FUN,STR "Eriksson, Lonnroth: J Int Med, 225, 43-45, 1989
FUN,PEP,EXP "Gartung &: EMBO J, 4, 1725-1730, 1985
FUN,PEP,EXP "Graham &: PNAS, 83, N12, 4519-4523, 1986
FUN,PEP,EXP "Hoflack, Kornfeld: JBC, 262, 123-129, 1987
FUN,PEP,EXP "Hoflack, Kornfeld: JBC, 260, 12008-12014, 1985a
FUN,PEP,EXP "Hoflack, Kornfeld: PNAS, 82, 4428-4432, 1985b
FUN,MEB,MOP "Kiess W &: JBC, 263, 9339-9443, 1988
FUN,PEP,EXP "Kornfeld S: J Clin Invest, 77, 1-6, 1986
LOC,EVO "Laureys G &: Genomics, 3, 224-229, 1988
PRO,SEQ,MOP "Morgan DO &: Nature, 329, 301-307, 1987
FUN,PEP,EXP "Nishimoto I &: JBC, 262, N25, 12120-12126, 1987
FUN,PEP,EXP "Nolan &: J Cell Biochem, 35, 137-151, 1987
PRO,SEQ,MOP "Oshima A &: JBC, 263, N5, 2553-2562, 1988
REV,FUN,STR "Roth RA: Science, 239, (11 Mar), 1269-1271, 1988
FUN,PEP,EXP "Roth RA &: BBRC, 149, N2, 600-606, 1987
FUN,PEP,EXP "Stein &: EMBO J, 6, 2677-2681, 1987
FUN,MEB,MOP "Waheed A &: BBRC, 152, 1248-1254, 1988

SWI

SWISSPROT: P11717

KEY

recp, lys, horm

CLA

coding, basic

LOC

06 q25.3

MIM

MIM: 147280

SYN

MPRI MPRCI

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