Gene: [07p13/GCK] glucokinase (hexokinase 4, maturity onset diabetes of the young 2); hexokinase 4 (liver and pancreatic) (glucokinase); maturity onset diabetes of the young 2 (MIM:125851);
FUN | Systematic name: ATP:D-hexose 6-phosphotransferase. Catalyzes reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. ITP and dATP can act as donors." |
FAG | About hexokinases see GEM:10q22/HK1. |
EXP | Liver isozyme (SwissProt: HXKH Q05810) and pancreatic isozyme (SwissProt: HXKP P35557) are produced by alternative splicing." |
REL | GEM:02p223/GCKR. |
REF | SEQ "Koranyi LI &:
Diabetes, 41, 807-811, 1992 LOC,LIN "Matsutani A &: Genomics, 12, 319-325, 1992 LOC,LIN "Mishra SK &: Genomics, 12, 326-334, 1992 COD,POL,LOC "Nishi S &: Diabetologia, 35, 743-747, 1992 SEQ "Tanizawa Y &: Mol Endocrinol, 6, 1070-1081, 1992 |
SWI | SWISSPROT: Q05810; HXKP P35557 |
KEY | carb, mtbd |
CLA | coding, basic |
LOC | 07 p13 |
MIM | MIM: 138079 |
EZN | ENZYME: 2.7.1.1 |
Ссылки:
- Gene: [20q1/HNF4A] hepatocyte nuclear factor 4, alpha; transcription factor 14, hepatic; maturity onset diabetes of the young 1 (MIM:125850); [TCF14 MODY1 ]
- Gene: [02q36/IRS1] insulin receptor substrate 1; noninsulin-dependent diabetes mellitus (NIDDM, MIM:125853); [HIRS-1 ]
- Гены гексокиназы
- Карта белка глюкокиназы
