Gene: [20q1/HNF4A] hepatocyte nuclear factor 4, alpha; transcription factor 14, hepatic; maturity onset diabetes of the young 1 (MIM:125850); [TCF14 MODY1 ]

COM

Argyrokastritis-1997 mapped TCF14 gene to Chr 20q12-13.1 between PLCG1 gene (GEM:20q1/PLCG1) and marker D20S17."

LIN

Bell-1991 found tight linkage MODY1 with a DNA polymorphism in the adenosine deaminase gene (GEM:20q1311/ADA)."

FAG

On other MODY (maturity onset diabetes of the young) types see: type 2 (GEM:07p13/GCK, glucokinase) and type 3 (GEM:12q243/TCF1)."

REF

CLO,LOC "Argyrokastritis A &: Hum Genet, 99, N2, 233-236, 1997
LIN,LOC "Bell GI &: PNAS, 88, 1484-1488, 1991
CLO,SEQ,STR "Chartier FL &: Gene, 147, 269-272, 1994
LIN,LOC "Rothschild CB &: Genomics, 13, 560-564, 1992
LOC,MAP "Stoffel M &: PNAS, 93, N9, 3937-3941, 1996
MUT "Yamagata K &: Nature, 384, N6608, 458-460, 1996

SWI

 SWISSPROT: P41235

KEY

trc, recp, mfd, horm

CLA

coding, basic

LOC

20 q12-13.1

MIM

 MIM: 600281

SYN

TCF14 MODY1

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