Gene: [12q243/TCF1] transcription factor 1, hepatic; LF-B1, albumin proximal factor; hepatic nuclear factor 1 (HNF1); maturity onset diabetes of the young 3 (MIM:600496); non-insulin-dependent diabetes mellitus (common, type 2) 2 (MIM:601407, MIM:125853); [HNF1 MODY3 ]
FAG | The following genes coding for transcription factors have been found: GEM:17q1/TCF2; GEM:19p133/TCF3; GEM:00.0/TCF4; GEM:10q21/TFAM (TCF6,TCF6L2); GEM:07p/TCF6L1; GEM:11q/TCF6L3; GEM:05q311/TCF7; GEM:10p112/TCF8; GEM:02p11/TCF9; GEM:17q213/NFE2L1(TCF11); GEM:15q21/TCF12; GEM:11p152/TEAD1(=TCF13); GEM:12p13/TEAD4(=TCF13L1); GEM:20q1/HNF4A(TCF14); GEM:20p13/TCF15; GEM:05q353/TCF17; GEM:06p213/TCF19; GEM:00.0/TCF20; GEM:01q21/TCFL1. See also GEM:14q1/HNF3A; GEM:20p11/HNF3B; GEM:19q13/HNF3G." |
REF | MUT,PAT "Frayling TM
&: Diabetes, 46, 720-725, 1997 MUT,PAT "Hansen T &: Diabetes, 46, 726-730, 1997 MUT,PAT "Lehto M &: J Clin Invest, 99, 582-591, 1997 LIN,LOC "Lesage S &: Diabetes, 44, 1243-1247, 1995 LIN,LOC "Mahtani MM &: Nature Genet, 14, 90-94, 1996 LOC "Menzel S &: Diabetes, 44, 1408-1413, 1995 EVO,EAG "Ruvinsky I, Silver LM: Genomics, 40, 262-266, 1997 POL "Urhammer SA &: Diabetologia, 40, 473-475, 1997 LIN,LOC,MUT "Vaxillaire M &: Nature Genet, 9, 418-423, 1995 LOC,MUT "Yamagata K &: Nature, 384, 455-457, 1996 |
SWI | SWISSPROT: P20823 |
KEY | trc, mfd, horm |
CLA | coding, basic |
LOC | 12 q24.3 |
MIM | MIM: 142410 |
SYN | HNF1 MODY3 |
Ссылки:
- HNF1 (HNF1 альфа, LFB1) белки: общие сведения
- Gene: [17q23/TBX2] T-box 2;
- Gene: [02q36/IRS1] insulin receptor substrate 1; noninsulin-dependent diabetes mellitus (NIDDM, MIM:125853); [HIRS-1 ]
- Gene: [10q22/PCBD] pterin-4-alpha-carbinolamine dehydratase; dimerization cofactor of hepatocyte nuclear factor 1 alpha; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor; hyperphenylalaninemia, mild (MIM:264070);
- Gene: [02q/NIDDM1] non-insulin-dependent diabetes mellitus (common, type 2) 1 (MIM:125853);
