Gene: [17q213/NFE2L1] transcription factor 11 (basic leucine zipper type; HBZ17; LCR-F1); nuclear factor, erythroid-derived 2-like 1; NFE2-related transcription factor 1 (NRF1); locus control region, beta (MIM:152424); [NRF1 LCRB LCR ]
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COM |
By fluorescence in situ hybridization, the NFE2L1 gene was mapped to Chr 17q22 (Luna-1994) and to 17q21.3 (Chan-1995)." |
|
MOP |
One of the simplest DNA-binding motifs, the basic leucine zipper (bZIP), has been identified in many different transcriptional regulatory proteins in diverse organisms. The bZIP motif is made up of 2 distinct but usually adjacent subdomains, a DNA-binding or basic domain that interacts with sequence-specific DNA and a dimerization or leucine zipper domain." |
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FAG |
Transcription factors can be grouped into classes on the basis of their structural motifs for recognition. The structure of the derived protein and other evidence identified TCF11 as a member of the bZIP family of transcription factors." |
|
POL |
Interethnic polymorphism of 1 segment of the NFE2L1/LCRB region was shown in sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat were observed in strong linkage disequilibrium with each of the 5 major beta-S haplotypes (Perichon-1993)." |
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REF |
CLO,EXP "Caterina JJ &: NAR, 22, N12, 2383-2391, 1994 LOC "Chan JY &: Hum Genet, 95, 265-269, 1995 CLO,SEQ "Chan JY &: PNAS, 90, N23, 11371-11375, 1993 PRO,LOC,SEQ "Luna L &: Genomics, 22, N3, 553-562, 1994 CLO,POL "Perichon B &: Hum Genet, 91, N5, 464-468, 1993 |
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KEY |
trc |
|
CLA |
coding, basic |
|
LOC |
17 q21.3? |
|
MIM |
MIM: 163260 |
|
SYN |
NRF1 LCRB LCR |
Ссылки:
- Gene: [12q243/TCF1] transcription factor 1, hepatic; LF-B1, albumin proximal factor; hepatic nuclear factor 1 (HNF1); maturity onset diabetes of the young 3 (MIM:600496); non-insulin-dependent diabetes mellitus (common, type 2) 2 (MIM:60140
- Gene: [12q13/NFE2] nuclear factor, erythroid-derived 2, 45kD;
