Gene: [17q213/NFE2L1] transcription factor 11 (basic leucine zipper type; HBZ17; LCR-F1); nuclear factor, erythroid-derived 2-like 1; NFE2-related transcription factor 1 (NRF1); locus control region, beta (MIM:152424); [NRF1 LCRB LCR ]

COM

By fluorescence in situ hybridization, the NFE2L1 gene was mapped to Chr 17q22 (Luna-1994) and to 17q21.3 (Chan-1995)."

MOP

One of the simplest DNA-binding motifs, the basic leucine zipper (bZIP), has been identified in many different transcriptional regulatory proteins in diverse organisms. The bZIP motif is made up of 2 distinct but usually adjacent subdomains, a DNA-binding or basic domain that interacts with sequence-specific DNA and a dimerization or leucine zipper domain."

FAG

Transcription factors can be grouped into classes on the basis of their structural motifs for recognition. The structure of the derived protein and other evidence identified TCF11 as a member of the bZIP family of transcription factors."

POL

Interethnic polymorphism of 1 segment of the NFE2L1/LCRB region was shown in sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat were observed in strong linkage disequilibrium with each of the 5 major beta-S haplotypes (Perichon-1993)."

REF

CLO,EXP "Caterina JJ &: NAR, 22, N12, 2383-2391, 1994
LOC "Chan JY &: Hum Genet, 95, 265-269, 1995
CLO,SEQ "Chan JY &: PNAS, 90, N23, 11371-11375, 1993
PRO,LOC,SEQ "Luna L &: Genomics, 22, N3, 553-562, 1994
CLO,POL "Perichon B &: Hum Genet, 91, N5, 464-468, 1993

KEY

trc

CLA

coding, basic

LOC

17 q21.3?

MIM

MIM: 163260

SYN

NRF1 LCRB LCR

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