Gene: [07p22/PDGFA] platelet-derived growth factor, alpha polypeptide; [PDGF1 ]
MOP | An active PDGF protein is a heterodimer composed of related but different peptides A and B, the latter being known as protooncogene SIS mapped in Chr 22q1 (GEM:22q1/PDGFB)." |
HIS | There was substantial diversity of opinion regarding the regional localization of this gene: originally it was mapped to Chr 7pt-q22, on the basis of the results of PDGFA cloned cDNA blot hybridization with samples of gDNA from himan-mouse cell hybrids (Betsholz-1986); then a more precise localization, Chr 7p21-22, was determined (Bonthron-1988) in experiments on the cloned gene in situ hybridization on chromosome. However, Stenman-1988 demonstrated the Chr 7q11.23 localization, using the same method." |
GEN | The gene length is 24 kb. Exons: 7; introns: 6. |
REF | CLO,SEQ,LOC "Betsholtz C &: Nature, 320, N6064, 695-699,
1986 GEN,SEQ,LOC "Bonthron DT &: PNAS, 85, N5, 1492-1496, 1988 FUN "Richardson &: Cell, 53, (22 Apr), 309-319, 1988 FUN "Ross &: Cell, 46, 155-169, 1986 LOC,MOL "Stenman G &: Exp Cell Res, 178, N1, 180-184, 1988 |
SWI | SWISSPROT: P04085 |
KEY | onc, cyk, neu, hem |
CLA | coding, basic |
LOC | 07 p22 |
MIM | MIM: 173430 |
SYN | PDGF1 |
