Gene: [07p22/PDGFA] platelet-derived growth factor, alpha polypeptide; [PDGF1 ]

MOP

An active PDGF protein is a heterodimer composed of related but different peptides A and B, the latter being known as protooncogene SIS mapped in Chr 22q1 (GEM:22q1/PDGFB)."

HIS

There was substantial diversity of opinion regarding the regional localization of this gene: originally it was mapped to Chr 7pt-q22, on the basis of the results of PDGFA cloned cDNA blot hybridization with samples of gDNA from himan-mouse cell hybrids (Betsholz-1986); then a more precise localization, Chr 7p21-22, was determined (Bonthron-1988) in experiments on the cloned gene in situ hybridization on chromosome. However, Stenman-1988 demonstrated the Chr 7q11.23 localization, using the same method."

GEN

The gene length is 24 kb. Exons: 7; introns: 6.

REF

CLO,SEQ,LOC "Betsholtz C &: Nature, 320, N6064, 695-699, 1986
GEN,SEQ,LOC "Bonthron DT &: PNAS, 85, N5, 1492-1496, 1988
FUN "Richardson &: Cell, 53, (22 Apr), 309-319, 1988
FUN "Ross &: Cell, 46, 155-169, 1986
LOC,MOL "Stenman G &: Exp Cell Res, 178, N1, 180-184, 1988

SWI

SWISSPROT: P04085

KEY

onc, cyk, neu, hem

CLA

coding, basic

LOC

07 p22

MIM

MIM: 173430

SYN

PDGF1

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