Gene: [04q12/PDGFRA] platelet-derived growth factor receptor, alpha polypeptide;

FAG

[1] Biochemical studies have revealed at least two PDGF receptor classes, which are possibly specific to different isoforms of the platelet cytokine (A type receptor for PDGF-AA and -AB isoforms and B receptor for PDGF-BB isoform). The gene for this receptor beta-peptide is located in chromosome 5 (GEM:05q3/PDGFRB). The PDGFR-like gene is mapped: GEM:08p2/PRLTS.
[2] The PDGF per se is a heterodimer; its A and B peptides are encoded by different but evolutionary related genes, which are mapped in chromosomes 7 and 22 (see GEM:07p22/PDGFA and GEM:22q1/PDGFB)."

EVO

Significant homology was demonstrated between PDGFR, KIT protooncogene (GEM:04q12/KIT) and macrophage growth factor (GEM:01p/CSF1)."

REF

IDN,FUN "Bishayee &: PNAS, 83, N18, 6756-6760, 1986
PRO,LOC "Disteche &: CCG, 51, (HGM10), 990, 1989
IDN,CLO,SEQ,EXP "Matsui T &: Science, 243, 800-804, 1989
LOC,MAP "Spritz RA &: Genomics, 22, 431-436, 1994
FAG,EVO "see GEM:05q3/PDGFRB

SWI

 SWISSPROT: P16234

KEY

onc, cyk, mem, recp

CLA

coding, basic

LOC

04 q12

MIM

 MIM: 173490

EZN

 ENZYME: 2.7.1.112

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