Gene: [09q32/ORM1] orosomucoid 1 (alpha-1-acid glycoprotein 1); [AGP1 ]

COM

[1] The MIM catalogue indicates the regional location as q34.1-34.3, with reference to Allderdice-1986, however, the conclusions of this report are disputed (Zuffardi-1989, Webb-1988).
[2] The HGM catalogue indicates for ORM1 location a more extended region, q31-t. With account for the data on the localization of the gene for the second orosomucoid isoform, which is closely linked to ORM1, the GEM catalogue localizes both genes to q34."

GEN

The UPS vicinity contains five Alu-repeats; the 5'-UTL region is homologous to those of alpha-1 antitrypsin and haptoglobin genes. An approximate gene structure is like the following: EX1, INT=450 bp; EX2, INT=216 bp; EX3, INT=700 bp; EX4, INT=175 bp; EX5, INT=1090 bp; EX6."

ASS

The serum level of the protein is increased in acute inflammation, i.e. the protein may be assigned to the class of acute-phase reactants."

MAP

Loci: GEM:09q32/ORM2; GEM:09q341/AK1; GEM:09q34/ABO.
[1] ORM1/ORM2-[17cM]-AK1-[13cM]-ABO.
[1a] ORM-[27cM]-ABO.
[1b] ORM1-[3.3kb]-ORM2."

REF

LOC,LIN,CYG,COM "Allderdice PW &: AJHG, 39, 612-617, 1986
PRO,COD,SEQ,EXP "Board PG &: Gene, 44, 127-131, 1986
GEN,SEQ "Dente L &: EMBO J, 6, 2289-2296, 1987
PRO,COD,SEQ,EXP "Dente L &: NAR, 13, N11, 3941-3952, 1985
PRO,COD,SEQ,EXP "Merritt CM, Board PG: Gene, 66, 97-106, 1988
LOC,CYG,PRO,FAG "Rocchi M &: Hum Genet, 74, 30-33, 1986
LOC,LIN,CYG,COM "Webb GC &: CCG, 47, 18-21, 1988
LOC,LIN,CYG,COM "Zuffardi O &: Hum Genet, 82, 17-19, 1989

SWI

SWISSPROT: P02763

KEY

hem, serp

CLA

coding, basic

LOC

09 q32

MIM

MIM: 138600

SYN

AGP1