Gene: [09q32/ORM2] orosomucoid 2 (alpha-1-acid glycoprotein 2); [AGP2 ]

COM

On the controversial data on the regional localization of ORM locus, see GEM:09q32/ORM1 and GEM:09q341/AK1."

GEN

The gene length is 3.5 kb. Exons: 6; introns: 5. The UPS vicinity contains one Alu-repeat. EX1= 129 bp: 5'-UTL 15 bp, initiator ATG=methionine + 114 bp (38 amino acids), INT1= 416 bp; EX2= 143 bp (48 amino acids), INT2= 219 bp; EX3= 71 bp
(23 amino acids), INT3= 705 bp; EX4= 108 bp (36 amino acids), INT4= 151 bp; EX5=104 bp
(35 amino acids), INT5=1141 bp; EX6= 168 bp: (21 amino acids), terminator TAG, 3'-UTL= 105 bp."

MOP

The protein contains 201 amino acid residues, MM 40 kD, 45% of the molecular mass is accounted for carbohydrate residues."

ASS

The serum level of the protein is increased in acute inflammation, i.e. the protein may be assigned to the class of acute-phase reactants."

MAP

Loci: GEM:09q32/ORM1; GEM:09q341/AK1; GEM:09q34/ABO.
[1] See GEM:09q32/ORM1."

REF

CLO,SEQ,EXP "Board PG &: Gene, 44, 127-131, 1986
GEN,STR "Dente L &: EMBO J, 6, 2289-2296, 1987
CLO,SEQ,EXP "Merritt CM, Board PG: Gene, 66, 97-106, 1988
LOC,FAG "Webb GC &: CCG, 47, 18-21, 1988
LOC,FAG "see also GEM:09q32/ORM1

SWI

SWISSPROT: P19652

KEY

hem, serp

CLA

coding, basic

LOC

09 q32

MIM

MIM: 138610

SYN

AGP2