Gene: [10q112/ALOX5] arachidonate 5-lipoxygenase (leukotrien A4 synthase); arachidonate 5-lipoxygenase, variable expression of;
GEN | The gene length is 82 kb. Exons: 14; they are 82-613 bp in length. |
MOP | The size of
the mature transcript is 2.7 kb. The protein have MM 77839D (673 amino acids)." |
FUN | The enzyme catalyzes the first two steps of the synthesis of peptidoleukotriens and a hemotaxis factor, leukotrien B4, which play an important role in inflammatory and allergic responses. The cytoplasmic enzyme, which acts in the presence of ATP and calcium ions, was isolated from leukocytes and red blood cells, as well as from lung and placenta tissues." |
REL | GEM:00.0/ALOX5AP; GEM:17p131/ALOX12; GEM:17^/ALOX12P1; GEM:00.0/ALOX12P2; GEM:17^/ALOX15." |
REF | PRO,SEQ,MOP "Dixon RAF
&: PNAS, 85, N2, 416-420, 1988 REV,FUN "Ford-Hutchinson, Letts: Hypertension, 8, (Ii.), 44-49, 1986 LOC "Funk CD &: PNAS, 89, 3962-3966, 1992 GEN,SEQ,MOP "Funk CD &: PNAS, 86, 2587-2591, 1989 MUT "In KH &: J Clin Invest, 99, N5, 1130-1137, 1997 PRO,SEQ,MOP "Matsumoto T &: PNAS, 85, N1, 26-30, 1988 REV,FUN "Shimizu &: Int J Biochem, 20, N7, 661-666, 1988 LOC "Tunnacliffe A &: Hum Genet, 93, 313-318, 1994 |
SWI | SWISSPROT: P09917 |
KEY | hem, card, imm, mfd, lip |
CLA | coding, basic |
LOC | 10 q11.2 |
MIM | MIM: 152390 |
EZN | ENZYME: 1.13.11.34 |
