Gene: [11p151/LDHA] lactate dehydrogenase A (M chain; muscle); exertional myoglobinuria (lactate dehydrogenase A deficiency);

GEN

The gene length is 12 kb.

FUN

Systematic name: (S)-lactate:NAD+ oxidoreductase. The reaction catalyzed: (S)-lactate + NAD+ = pyruvate + NADH."

FAG

[1] Five human LDHA-like sequences have been found: GEM:04p1/LDHAL1; GEM:01q4/LDHAL2; GEM:02^/LDHAL3; GEM:09^/LDHAL4; GEM:10^/LDHAL5.
[2] Two genes coding for other isoforms of lactate dehydrogenase (GEM:12p12/LDHB; GEM:11p151/LDHC) and three LDH-like sequences (GEM:13^/LDHBL1; GEM:0X^/LDHBP; and GEM:11p1/LDHCL) have been mapped. According to previous data (Sakai-1987, Edwards-1987, Li-1988) there are three to five other LDH-like sequences in the human genome, which have not been mapped yet."

REF

LOC,CYG "Boone &: PNAS, 69, 510-514, 1972
SEQ,GEN,FAG "Chung FZ &: Biochem J, 231, 537-541, 1985
MOP,FAG "Edwards &: Dev Genet, 8, 219-232, 1987
PRO,LOC,LIN "Gerhard &: CCG, 46, (HGM9), 619, 1987
FOG,PAT "Kanno &: Clin Chim Acta, 108, 267-276, 1980
LOC,MAP "Lebo RV &: Hum Genet, 69, 316-320, 1985
LOC,MAP "Lewis WH &: Hum Genet, 71, 249-253, 1985
MOP,FAG "Li SS &: CCG, 48, 16-18, 1988
FOG,PAT "Maekawa M &: AJHG, 39, 232-238, 1986
FOG,PAT "Maekawa M &: AJHG, 36, 1204-1214, 1984
MOP,FAG "Sakai &: Biochem J, 242, 619-622, 1987
SEQ,PRO,FAG "Tsujibo H &: Eur J Biochem, 147, 9-15, 1985
LOC,MAP "Van Heyningen &: CCG, 40, (HGM8), 768, 1985
LOC,MAP "Yang-Feng TL &: Hum Genet, 74, 331-334, 1986

KEY

glyc, myo

CLA

coding, basic

LOC

11 p15.1

MIM

MIM: 150000

EZN

ENZYME: 1.1.1.27

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