Gene: [11p155/CTSD] cathepsin D (lysosomal aspartyl protease);
|
FUN |
Systematic name: not known. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin." |
|
FAG |
[1] The data (Murnane-1985) on the localization a cluster of cathepsin
B, H, and L genes in 11p13-11 were not confirmed, although the
cathepsin D gene appeared to be located in 11p15.5.
[2] On the localization of human cathepsin genes, see GEM:08p22/CTSB." |
|
REF |
CLO,SEQ,EXP "Faust PL &: PNAS, 82, N15, 4910-4914, 1985 LOC,CYG "Hasilik &: CCG, 32, (HGM6), 284, 1982 LOC,LIN,CYG "Henry &: CCG, 51, (HGM10), 1013, 1989 FAG "Murnane &: AJHG, 37, A33, 1985 LOC,LIN,MOL "Qin &: CCG, 46, (HGM9), 678, 1987 |
|
KEY |
pep, lys |
|
CLA |
coding, basic |
|
LOC |
11 p15.5 |
|
MIM |
MIM: 116840 |
|
EZN |
ENZYME: 3.4.23.5 |
